An exploratory study of adolescent response to fluoxetine using psychological and biological predictors
Background Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study used psychological and biological markers for (retrospective) prediction of treatment-response to fluoxetine in depressed and/or anxi...
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doaj-07818ce2dba84e0fa378c160332067d12020-11-24T20:40:14ZengPeerJ Inc.PeerJ2167-83592018-01-016e424010.7717/peerj.4240An exploratory study of adolescent response to fluoxetine using psychological and biological predictorsAda H. Zohar0Tamar Eilat1Maya Amitai2Michal Taler3Romi Bari4Alon Chen5Alan Apter6Avraham Weizman7Silvana Fennig8Graduate Program in Clinical Psychology, Ruppin Academic Center, Emek Hefer, IsraelGraduate Psychology in Clinical Psychology, Ruppin Academic Center, Emek Hefer, IsraelThe Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, Rehovot, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelPsychological Medicine, Schneider Children’s Medical Center of Israel, Petah Tikva, IsraelThe Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, Rehovot, IsraelPsychological Medicine, Schneider Children’s Medical Center of Israel, Petah Tikva, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelPsychological Medicine, Schneider Children’s Medical Center of Israel, Petah Tikva, IsraelBackground Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study used psychological and biological markers for (retrospective) prediction of treatment-response to fluoxetine in depressed and/or anxious adolescents. Methods Forty-one consecutive adolescent outpatients with a primary diagnosis of severe affective and/or anxiety disorders were assessed and treated with an open-label 8-week trial of fluoxetine. Type D personality was assessed with the 14-item questionnaire, the DS14. In addition, TNFα, IL-6, and IL-1b were measured pre- and post-treatment. Results There was an elevation of Type D personality in patients, compared to the adolescent population rate. Post-treatment, 44% of patients were classified as non-responders; the relative risk of non-response for Type D personality patients was 2.8. Binary logistic regression predicting response vs. non-response showed a contribution of initial TNFα levels as well as Type D personality to non-response. Conclusions In this exploratory study, the most significant contributor to non-response was Type D personality. However, the measurement of Type D was not prospective, and thus may be confounded with psychiatric morbidity. The measurement of personality in psychiatric settings may contribute to the understanding of treatment response and have clinical utility.https://peerj.com/articles/4240.pdfFluoxetineAdolescentTreatment responseEx post-facto studyType D personalityPersonality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ada H. Zohar Tamar Eilat Maya Amitai Michal Taler Romi Bari Alon Chen Alan Apter Avraham Weizman Silvana Fennig |
spellingShingle |
Ada H. Zohar Tamar Eilat Maya Amitai Michal Taler Romi Bari Alon Chen Alan Apter Avraham Weizman Silvana Fennig An exploratory study of adolescent response to fluoxetine using psychological and biological predictors PeerJ Fluoxetine Adolescent Treatment response Ex post-facto study Type D personality Personality |
author_facet |
Ada H. Zohar Tamar Eilat Maya Amitai Michal Taler Romi Bari Alon Chen Alan Apter Avraham Weizman Silvana Fennig |
author_sort |
Ada H. Zohar |
title |
An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_short |
An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_full |
An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_fullStr |
An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_full_unstemmed |
An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_sort |
exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
publisher |
PeerJ Inc. |
series |
PeerJ |
issn |
2167-8359 |
publishDate |
2018-01-01 |
description |
Background Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study used psychological and biological markers for (retrospective) prediction of treatment-response to fluoxetine in depressed and/or anxious adolescents. Methods Forty-one consecutive adolescent outpatients with a primary diagnosis of severe affective and/or anxiety disorders were assessed and treated with an open-label 8-week trial of fluoxetine. Type D personality was assessed with the 14-item questionnaire, the DS14. In addition, TNFα, IL-6, and IL-1b were measured pre- and post-treatment. Results There was an elevation of Type D personality in patients, compared to the adolescent population rate. Post-treatment, 44% of patients were classified as non-responders; the relative risk of non-response for Type D personality patients was 2.8. Binary logistic regression predicting response vs. non-response showed a contribution of initial TNFα levels as well as Type D personality to non-response. Conclusions In this exploratory study, the most significant contributor to non-response was Type D personality. However, the measurement of Type D was not prospective, and thus may be confounded with psychiatric morbidity. The measurement of personality in psychiatric settings may contribute to the understanding of treatment response and have clinical utility. |
topic |
Fluoxetine Adolescent Treatment response Ex post-facto study Type D personality Personality |
url |
https://peerj.com/articles/4240.pdf |
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