The role of dysfunctional HDL in atherosclerosis

The role of dysfunctional HDL in atherosclerosis

This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in re...

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Bibliographic Details
Main Authors: Mohamad Navab, Srinivasa T. Reddy, Brian J. Van Lenten, G.M. Anantharamaiah, Alan M. Fogelman
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Lipid Research
Subjects:
inflammation
high density lipoprotein
LDL
mimetic peptides
L-4F
D-4F
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520306027
Description
Summary:This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.
ISSN:0022-2275

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