The role of dysfunctional HDL in atherosclerosis

The role of dysfunctional HDL in atherosclerosis

This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in re...

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Main Authors: Mohamad Navab, Srinivasa T. Reddy, Brian J. Van Lenten, G.M. Anantharamaiah, Alan M. Fogelman
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Journal of Lipid Research
Subjects:
inflammation
high density lipoprotein
LDL
mimetic peptides
L-4F
D-4F
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520306027
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spelling doaj-0784287469bc45cf897cd5feb9c255a02021-04-28T05:55:48ZengElsevierJournal of Lipid Research0022-22752009-01-0150S145S149The role of dysfunctional HDL in atherosclerosisMohamad Navab0Srinivasa T. Reddy1Brian J. Van Lenten2G.M. Anantharamaiah3Alan M. Fogelman4To whom correspondence should be addressed; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.http://www.sciencedirect.com/science/article/pii/S0022227520306027inflammationhigh density lipoproteinLDLmimetic peptidesL-4FD-4F
collection DOAJ
language English
format Article
sources DOAJ
author Mohamad Navab
Srinivasa T. Reddy
Brian J. Van Lenten
G.M. Anantharamaiah
Alan M. Fogelman
spellingShingle Mohamad Navab
Srinivasa T. Reddy
Brian J. Van Lenten
G.M. Anantharamaiah
Alan M. Fogelman
The role of dysfunctional HDL in atherosclerosis
Journal of Lipid Research
inflammation
high density lipoprotein
LDL
mimetic peptides
L-4F
D-4F
author_facet Mohamad Navab
Srinivasa T. Reddy
Brian J. Van Lenten
G.M. Anantharamaiah
Alan M. Fogelman
author_sort Mohamad Navab
title The role of dysfunctional HDL in atherosclerosis
title_short The role of dysfunctional HDL in atherosclerosis
title_full The role of dysfunctional HDL in atherosclerosis
title_fullStr The role of dysfunctional HDL in atherosclerosis
title_full_unstemmed The role of dysfunctional HDL in atherosclerosis
title_sort role of dysfunctional hdl in atherosclerosis
publisher Elsevier
series Journal of Lipid Research
issn 0022-2275
publishDate 2009-01-01
description This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.
topic inflammation
high density lipoprotein
LDL
mimetic peptides
L-4F
D-4F
url http://www.sciencedirect.com/science/article/pii/S0022227520306027
work_keys_str_mv AT mohamadnavab theroleofdysfunctionalhdlinatherosclerosis
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