The role of dysfunctional HDL in atherosclerosis
This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in re...
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2009-01-01
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doaj-0784287469bc45cf897cd5feb9c255a02021-04-28T05:55:48ZengElsevierJournal of Lipid Research0022-22752009-01-0150S145S149The role of dysfunctional HDL in atherosclerosisMohamad Navab0Srinivasa T. Reddy1Brian J. Van Lenten2G.M. Anantharamaiah3Alan M. Fogelman4To whom correspondence should be addressed; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679; Atherosclerosis Research Unit, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.http://www.sciencedirect.com/science/article/pii/S0022227520306027inflammationhigh density lipoproteinLDLmimetic peptidesL-4FD-4F |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohamad Navab Srinivasa T. Reddy Brian J. Van Lenten G.M. Anantharamaiah Alan M. Fogelman |
spellingShingle |
Mohamad Navab Srinivasa T. Reddy Brian J. Van Lenten G.M. Anantharamaiah Alan M. Fogelman The role of dysfunctional HDL in atherosclerosis Journal of Lipid Research inflammation high density lipoprotein LDL mimetic peptides L-4F D-4F |
author_facet |
Mohamad Navab Srinivasa T. Reddy Brian J. Van Lenten G.M. Anantharamaiah Alan M. Fogelman |
author_sort |
Mohamad Navab |
title |
The role of dysfunctional HDL in atherosclerosis |
title_short |
The role of dysfunctional HDL in atherosclerosis |
title_full |
The role of dysfunctional HDL in atherosclerosis |
title_fullStr |
The role of dysfunctional HDL in atherosclerosis |
title_full_unstemmed |
The role of dysfunctional HDL in atherosclerosis |
title_sort |
role of dysfunctional hdl in atherosclerosis |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
2009-01-01 |
description |
This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity. |
topic |
inflammation high density lipoprotein LDL mimetic peptides L-4F D-4F |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520306027 |
work_keys_str_mv |
AT mohamadnavab theroleofdysfunctionalhdlinatherosclerosis AT srinivasatreddy theroleofdysfunctionalhdlinatherosclerosis AT brianjvanlenten theroleofdysfunctionalhdlinatherosclerosis AT gmanantharamaiah theroleofdysfunctionalhdlinatherosclerosis AT alanmfogelman theroleofdysfunctionalhdlinatherosclerosis AT mohamadnavab roleofdysfunctionalhdlinatherosclerosis AT srinivasatreddy roleofdysfunctionalhdlinatherosclerosis AT brianjvanlenten roleofdysfunctionalhdlinatherosclerosis AT gmanantharamaiah roleofdysfunctionalhdlinatherosclerosis AT alanmfogelman roleofdysfunctionalhdlinatherosclerosis |
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1721504913632002048 |