Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs

• Main Authors: Arijit Mondal, Sankhadip Bose, Sabyasachi Banerjee, Jayanta Kumar Patra, Jai Malik, Sudip Kumar Mandal, Kaitlyn L. Kilpatrick, Gitishree Das, Rout George Kerry, Carmela Fimognari, Anupam Bishayee
• Format: Article
• Language: English
• Published: MDPI AG 2020-09-01
• Series: Marine Drugs
• Subjects: marine; microbes; microalgae; cancer; prevention; therapy
• Online Access: https://www.mdpi.com/1660-3397/18/9/476

Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and research institutions in general. Secondary marine metabolites are looked at as a favorable source of potentially new pharmaceutically active compounds, having a vast structural diversity and diverse biological activities; therefore, this is an astonishing source of potentially new anticancer therapy. This review contains an extensive critical discussion on the potential of marine microbial compounds and marine microalgae metabolites as anticancer drugs, highlighting their chemical structure and exploring the underlying mechanisms of action. Current limitation, challenges, and future research pathways were also presented.