Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy

Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy

Cancer initiation and maintenance of the transformed cell state depend on altered cellular signaling and aberrant activities of transcription factors (TFs) that drive pathological gene expression in response to cooperating genetic lesions. Deciphering the roles of interacting TFs is therefore centra...

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Bibliographic Details
Main Authors: Eva Külshammer, Juliane Mundorf, Merve Kilinc, Peter Frommolt, Prerana Wagle, Mirka Uhlirova
Format: Article
Language:English
Published: The Company of Biologists 2015-10-01
Series:Disease Models & Mechanisms
Subjects:
Oncogene cooperation
Transcription factors
Drosophila
Epithelia
Cancer
Jun-N-terminal kinase
JNK
Online Access:http://dmm.biologists.org/content/8/10/1279

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