Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation.
BACKGROUND: Newly formed platelets are associated with increased aggregation and adverse outcomes in patients with coronary artery disease (CAD). The mechanisms involved in the regulation of platelet turnover in patients with CAD are largely unknown. AIM: To investigate associations between platelet...
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doaj-078e8f33bec943d99486c5a2b551568d2020-11-25T02:11:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8556610.1371/journal.pone.0085566Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation.Sanne Bøjet LarsenErik Lerkevang GroveAnne-Mette HvasSteen Dalby KristensenBACKGROUND: Newly formed platelets are associated with increased aggregation and adverse outcomes in patients with coronary artery disease (CAD). The mechanisms involved in the regulation of platelet turnover in patients with CAD are largely unknown. AIM: To investigate associations between platelet turnover parameters, thrombopoietin and markers of low-grade inflammation in patients with stable CAD. Furthermore, to explore the relationship between platelet turnover parameters and type 2 diabetes, prior myocardial infarction, smoking, age, gender and renal insufficiency. METHODS: We studied 581 stable CAD patients. Platelet turnover parameters (immature platelet fraction, immature platelet count, mean platelet volume, platelet distribution width and platelet large cell-ratio) were determined using automated flow cytometry (Sysmex XE-2100). Furthermore, we measured thrombopoietin and evaluated low-grade inflammation by measurement of high-sensitive CRP and interleukin-6. RESULTS: We found strong associations between the immature platelet fraction, immature platelet count, mean platelet volume, platelet distribution width and platelet large cell ratio (r = 0.61-0.99, p<0.0001). Thrombopoietin levels were inversely related to all of the platelet turnover parameters (r = -0.17--0.25, p<0.0001). Moreover, thrombopoietin levels were significantly increased in patients with diabetes (p = 0.03) and in smokers (p = 0.003). Low-grade inflammation evaluated by high-sensitive CRP correlated significantly, yet weakly, with immature platelet count (r = 0.10, p = 0.03) and thrombopoietin (r = 0.16, p<0.001). Also interleukin-6 correlated with thrombopoietin (r = 0.10, p = 0.02). CONCLUSION: In stable CAD patients, thrombopoietin was inversely associated with platelet turnover parameters. Furthermore, thrombopoietin levels were increased in patients with diabetes and in smokers. However, low-grade inflammation did not seem to have a substantial impact on platelet turnover parameters.http://europepmc.org/articles/PMC3897460?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sanne Bøjet Larsen Erik Lerkevang Grove Anne-Mette Hvas Steen Dalby Kristensen |
spellingShingle |
Sanne Bøjet Larsen Erik Lerkevang Grove Anne-Mette Hvas Steen Dalby Kristensen Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation. PLoS ONE |
author_facet |
Sanne Bøjet Larsen Erik Lerkevang Grove Anne-Mette Hvas Steen Dalby Kristensen |
author_sort |
Sanne Bøjet Larsen |
title |
Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation. |
title_short |
Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation. |
title_full |
Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation. |
title_fullStr |
Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation. |
title_full_unstemmed |
Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation. |
title_sort |
platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
BACKGROUND: Newly formed platelets are associated with increased aggregation and adverse outcomes in patients with coronary artery disease (CAD). The mechanisms involved in the regulation of platelet turnover in patients with CAD are largely unknown. AIM: To investigate associations between platelet turnover parameters, thrombopoietin and markers of low-grade inflammation in patients with stable CAD. Furthermore, to explore the relationship between platelet turnover parameters and type 2 diabetes, prior myocardial infarction, smoking, age, gender and renal insufficiency. METHODS: We studied 581 stable CAD patients. Platelet turnover parameters (immature platelet fraction, immature platelet count, mean platelet volume, platelet distribution width and platelet large cell-ratio) were determined using automated flow cytometry (Sysmex XE-2100). Furthermore, we measured thrombopoietin and evaluated low-grade inflammation by measurement of high-sensitive CRP and interleukin-6. RESULTS: We found strong associations between the immature platelet fraction, immature platelet count, mean platelet volume, platelet distribution width and platelet large cell ratio (r = 0.61-0.99, p<0.0001). Thrombopoietin levels were inversely related to all of the platelet turnover parameters (r = -0.17--0.25, p<0.0001). Moreover, thrombopoietin levels were significantly increased in patients with diabetes (p = 0.03) and in smokers (p = 0.003). Low-grade inflammation evaluated by high-sensitive CRP correlated significantly, yet weakly, with immature platelet count (r = 0.10, p = 0.03) and thrombopoietin (r = 0.16, p<0.001). Also interleukin-6 correlated with thrombopoietin (r = 0.10, p = 0.02). CONCLUSION: In stable CAD patients, thrombopoietin was inversely associated with platelet turnover parameters. Furthermore, thrombopoietin levels were increased in patients with diabetes and in smokers. However, low-grade inflammation did not seem to have a substantial impact on platelet turnover parameters. |
url |
http://europepmc.org/articles/PMC3897460?pdf=render |
work_keys_str_mv |
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