Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?
Objective: To study the effect of intrauterine instillation of human chorionic gonadotropin hormone (hCG) before embryo transfer (ET) on pregnancy outcomes in women undergoing in-vitro fertilization (IVF) cycles. Materials and Methods: The study was an age and anti-mullerian hormone (AMH) level-matc...
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Wolters Kluwer Medknow Publications
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doaj-07a2189323b64f79b69f68cfc64186002020-11-24T23:08:17ZengWolters Kluwer Medknow PublicationsMAMC Journal of Medical Sciences2394-74382018-01-0142828710.4103/mamcjms.mamcjms_18_18Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?Anjali TempePriyanka KhandeyDevender VermaNilanchali SinghObjective: To study the effect of intrauterine instillation of human chorionic gonadotropin hormone (hCG) before embryo transfer (ET) on pregnancy outcomes in women undergoing in-vitro fertilization (IVF) cycles. Materials and Methods: The study was an age and anti-mullerian hormone (AMH) level-matched case–control study. Total 80 women of age group 25 to 40 years were recruited who were undergoing IVF for mild male factor, tubal factor, or ovulatory dysfunction. Two groups were formed and age matched. Study group (n = 40) received 800 IU of hCG 5 min before ET, whereas control group (n = 40) underwent direct ET without prior instillation of hCG. The pregnancy outcomes were compared between the two groups. Result: Primary outcome was implantation rate (IR). IR was significantly higher in study (hCG) group as compared to control group (30.95% vs. 15.29%, P = 0.016). Secondary outcomes were clinical pregnancy rate and live birth rate. Study group had higher pregnancy rate as compared to control group, but the difference was not statistically significant (40% vs. 25%, P = 1.0). Live birth rate was higher in study group but not significant (35.5% vs. 22.5%, P = 0.35). Abortions were comparable in both the groups. Conclusion: Intrauterine hCG before ET significantly improves IR and resulted in better IVF outcomes.http://www.mamcjms.in/article.asp?issn=2394-7438;year=2018;volume=4;issue=2;spage=82;epage=87;aulast=TempeHuman chorionic gonadotropin hormone (hCG)implantationIn vitro fertilizationintrauterine hCG |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anjali Tempe Priyanka Khandey Devender Verma Nilanchali Singh |
spellingShingle |
Anjali Tempe Priyanka Khandey Devender Verma Nilanchali Singh Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles? MAMC Journal of Medical Sciences Human chorionic gonadotropin hormone (hCG) implantation In vitro fertilization intrauterine hCG |
author_facet |
Anjali Tempe Priyanka Khandey Devender Verma Nilanchali Singh |
author_sort |
Anjali Tempe |
title |
Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles? |
title_short |
Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles? |
title_full |
Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles? |
title_fullStr |
Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles? |
title_full_unstemmed |
Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles? |
title_sort |
does intrauterine instillation of human chorionic gonadotropin hormone (hcg) before embryo transfer (et) improve pregnancy outcomes in in-vitro fertilization (ivf) cycles? |
publisher |
Wolters Kluwer Medknow Publications |
series |
MAMC Journal of Medical Sciences |
issn |
2394-7438 |
publishDate |
2018-01-01 |
description |
Objective: To study the effect of intrauterine instillation of human chorionic gonadotropin hormone (hCG) before embryo transfer (ET) on pregnancy outcomes in women undergoing in-vitro fertilization (IVF) cycles. Materials and Methods: The study was an age and anti-mullerian hormone (AMH) level-matched case–control study. Total 80 women of age group 25 to 40 years were recruited who were undergoing IVF for mild male factor, tubal factor, or ovulatory dysfunction. Two groups were formed and age matched. Study group (n = 40) received 800 IU of hCG 5 min before ET, whereas control group (n = 40) underwent direct ET without prior instillation of hCG. The pregnancy outcomes were compared between the two groups. Result: Primary outcome was implantation rate (IR). IR was significantly higher in study (hCG) group as compared to control group (30.95% vs. 15.29%, P = 0.016). Secondary outcomes were clinical pregnancy rate and live birth rate. Study group had higher pregnancy rate as compared to control group, but the difference was not statistically significant (40% vs. 25%, P = 1.0). Live birth rate was higher in study group but not significant (35.5% vs. 22.5%, P = 0.35). Abortions were comparable in both the groups. Conclusion: Intrauterine hCG before ET significantly improves IR and resulted in better IVF outcomes. |
topic |
Human chorionic gonadotropin hormone (hCG) implantation In vitro fertilization intrauterine hCG |
url |
http://www.mamcjms.in/article.asp?issn=2394-7438;year=2018;volume=4;issue=2;spage=82;epage=87;aulast=Tempe |
work_keys_str_mv |
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