Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?

Objective: To study the effect of intrauterine instillation of human chorionic gonadotropin hormone (hCG) before embryo transfer (ET) on pregnancy outcomes in women undergoing in-vitro fertilization (IVF) cycles. Materials and Methods: The study was an age and anti-mullerian hormone (AMH) level-matc...

Full description

Bibliographic Details
Main Authors: Anjali Tempe, Priyanka Khandey, Devender Verma, Nilanchali Singh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:MAMC Journal of Medical Sciences
Subjects:
Online Access:http://www.mamcjms.in/article.asp?issn=2394-7438;year=2018;volume=4;issue=2;spage=82;epage=87;aulast=Tempe
id doaj-07a2189323b64f79b69f68cfc6418600
record_format Article
spelling doaj-07a2189323b64f79b69f68cfc64186002020-11-24T23:08:17ZengWolters Kluwer Medknow PublicationsMAMC Journal of Medical Sciences2394-74382018-01-0142828710.4103/mamcjms.mamcjms_18_18Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?Anjali TempePriyanka KhandeyDevender VermaNilanchali SinghObjective: To study the effect of intrauterine instillation of human chorionic gonadotropin hormone (hCG) before embryo transfer (ET) on pregnancy outcomes in women undergoing in-vitro fertilization (IVF) cycles. Materials and Methods: The study was an age and anti-mullerian hormone (AMH) level-matched case–control study. Total 80 women of age group 25 to 40 years were recruited who were undergoing IVF for mild male factor, tubal factor, or ovulatory dysfunction. Two groups were formed and age matched. Study group (n = 40) received 800 IU of hCG 5 min before ET, whereas control group (n = 40) underwent direct ET without prior instillation of hCG. The pregnancy outcomes were compared between the two groups. Result: Primary outcome was implantation rate (IR). IR was significantly higher in study (hCG) group as compared to control group (30.95% vs. 15.29%, P = 0.016). Secondary outcomes were clinical pregnancy rate and live birth rate. Study group had higher pregnancy rate as compared to control group, but the difference was not statistically significant (40% vs. 25%, P = 1.0). Live birth rate was higher in study group but not significant (35.5% vs. 22.5%, P = 0.35). Abortions were comparable in both the groups. Conclusion: Intrauterine hCG before ET significantly improves IR and resulted in better IVF outcomes.http://www.mamcjms.in/article.asp?issn=2394-7438;year=2018;volume=4;issue=2;spage=82;epage=87;aulast=TempeHuman chorionic gonadotropin hormone (hCG)implantationIn vitro fertilizationintrauterine hCG
collection DOAJ
language English
format Article
sources DOAJ
author Anjali Tempe
Priyanka Khandey
Devender Verma
Nilanchali Singh
spellingShingle Anjali Tempe
Priyanka Khandey
Devender Verma
Nilanchali Singh
Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?
MAMC Journal of Medical Sciences
Human chorionic gonadotropin hormone (hCG)
implantation
In vitro fertilization
intrauterine hCG
author_facet Anjali Tempe
Priyanka Khandey
Devender Verma
Nilanchali Singh
author_sort Anjali Tempe
title Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?
title_short Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?
title_full Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?
title_fullStr Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?
title_full_unstemmed Does Intrauterine Instillation of Human Chorionic Gonadotropin Hormone (hCG) Before Embryo Transfer (ET) Improve Pregnancy Outcomes in in-vitro Fertilization (IVF) Cycles?
title_sort does intrauterine instillation of human chorionic gonadotropin hormone (hcg) before embryo transfer (et) improve pregnancy outcomes in in-vitro fertilization (ivf) cycles?
publisher Wolters Kluwer Medknow Publications
series MAMC Journal of Medical Sciences
issn 2394-7438
publishDate 2018-01-01
description Objective: To study the effect of intrauterine instillation of human chorionic gonadotropin hormone (hCG) before embryo transfer (ET) on pregnancy outcomes in women undergoing in-vitro fertilization (IVF) cycles. Materials and Methods: The study was an age and anti-mullerian hormone (AMH) level-matched case–control study. Total 80 women of age group 25 to 40 years were recruited who were undergoing IVF for mild male factor, tubal factor, or ovulatory dysfunction. Two groups were formed and age matched. Study group (n = 40) received 800 IU of hCG 5 min before ET, whereas control group (n = 40) underwent direct ET without prior instillation of hCG. The pregnancy outcomes were compared between the two groups. Result: Primary outcome was implantation rate (IR). IR was significantly higher in study (hCG) group as compared to control group (30.95% vs. 15.29%, P = 0.016). Secondary outcomes were clinical pregnancy rate and live birth rate. Study group had higher pregnancy rate as compared to control group, but the difference was not statistically significant (40% vs. 25%, P = 1.0). Live birth rate was higher in study group but not significant (35.5% vs. 22.5%, P = 0.35). Abortions were comparable in both the groups. Conclusion: Intrauterine hCG before ET significantly improves IR and resulted in better IVF outcomes.
topic Human chorionic gonadotropin hormone (hCG)
implantation
In vitro fertilization
intrauterine hCG
url http://www.mamcjms.in/article.asp?issn=2394-7438;year=2018;volume=4;issue=2;spage=82;epage=87;aulast=Tempe
work_keys_str_mv AT anjalitempe doesintrauterineinstillationofhumanchorionicgonadotropinhormonehcgbeforeembryotransferetimprovepregnancyoutcomesininvitrofertilizationivfcycles
AT priyankakhandey doesintrauterineinstillationofhumanchorionicgonadotropinhormonehcgbeforeembryotransferetimprovepregnancyoutcomesininvitrofertilizationivfcycles
AT devenderverma doesintrauterineinstillationofhumanchorionicgonadotropinhormonehcgbeforeembryotransferetimprovepregnancyoutcomesininvitrofertilizationivfcycles
AT nilanchalisingh doesintrauterineinstillationofhumanchorionicgonadotropinhormonehcgbeforeembryotransferetimprovepregnancyoutcomesininvitrofertilizationivfcycles
_version_ 1725615086703214592