Phage Display Technology as a Powerful Platform for Antibody Drug Discovery
Antibody drugs with a high affinity and specificity are effective and safe for intractable diseases, such as cancers and autoimmune diseases. Furthermore, they have played a central role in drug discovery, currently accounting for eight of the top 20 pharmaceutical products worldwide by sales. Forty...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
|
Series: | Viruses |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4915/13/2/178 |
id |
doaj-07a3a8ba9f5b486ab0d8d76e196f2f94 |
---|---|
record_format |
Article |
spelling |
doaj-07a3a8ba9f5b486ab0d8d76e196f2f942021-01-26T00:06:36ZengMDPI AGViruses1999-49152021-01-011317817810.3390/v13020178Phage Display Technology as a Powerful Platform for Antibody Drug DiscoveryKazuya Nagano0Yasuo Tsutsumi1Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, JapanGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, JapanAntibody drugs with a high affinity and specificity are effective and safe for intractable diseases, such as cancers and autoimmune diseases. Furthermore, they have played a central role in drug discovery, currently accounting for eight of the top 20 pharmaceutical products worldwide by sales. Forty years ago, clinical trials on antibody drugs that were thought to be a magic bullet failed, partly due to the immunogenicity of monoclonal antibodies produced in mice. The recent breakthrough in antibody drugs is largely because of the contribution of phage display technology. Here, we reviewed the importance of phage display technology as a powerful platform for antibody drug discovery from various perspectives, such as the development of human monoclonal antibodies, affinity enhancement of monoclonal antibodies, and the identification of therapeutic targets for antibody drugs.https://www.mdpi.com/1999-4915/13/2/178phage display systemantibody drugsphage antibody library |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kazuya Nagano Yasuo Tsutsumi |
spellingShingle |
Kazuya Nagano Yasuo Tsutsumi Phage Display Technology as a Powerful Platform for Antibody Drug Discovery Viruses phage display system antibody drugs phage antibody library |
author_facet |
Kazuya Nagano Yasuo Tsutsumi |
author_sort |
Kazuya Nagano |
title |
Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_short |
Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_full |
Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_fullStr |
Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_full_unstemmed |
Phage Display Technology as a Powerful Platform for Antibody Drug Discovery |
title_sort |
phage display technology as a powerful platform for antibody drug discovery |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2021-01-01 |
description |
Antibody drugs with a high affinity and specificity are effective and safe for intractable diseases, such as cancers and autoimmune diseases. Furthermore, they have played a central role in drug discovery, currently accounting for eight of the top 20 pharmaceutical products worldwide by sales. Forty years ago, clinical trials on antibody drugs that were thought to be a magic bullet failed, partly due to the immunogenicity of monoclonal antibodies produced in mice. The recent breakthrough in antibody drugs is largely because of the contribution of phage display technology. Here, we reviewed the importance of phage display technology as a powerful platform for antibody drug discovery from various perspectives, such as the development of human monoclonal antibodies, affinity enhancement of monoclonal antibodies, and the identification of therapeutic targets for antibody drugs. |
topic |
phage display system antibody drugs phage antibody library |
url |
https://www.mdpi.com/1999-4915/13/2/178 |
work_keys_str_mv |
AT kazuyanagano phagedisplaytechnologyasapowerfulplatformforantibodydrugdiscovery AT yasuotsutsumi phagedisplaytechnologyasapowerfulplatformforantibodydrugdiscovery |
_version_ |
1724323419056504832 |