Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors
Background. Many epidemiological studies have investigated the risk factors for clonorchiasis, but endoscopic findings of this disease in endoscopic retrograde cholangiopancreatography (ERCP) have not been well characterized. In this study, we evaluated clonorchiasis in ERCP in patients with biliary...
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doaj-07a854ff0d254ac391d504cab58704a22020-11-25T02:13:40ZengHindawi LimitedBioMed Research International2314-61332314-61412020-01-01202010.1155/2020/29465412946541Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk FactorsGuolin Liao0Huaqiang Ruan1Peng Peng2Shiquan Liu3Jianfu Qin4Zhihai Liang5Guodu Tang6Mengbin Qin7Jie’an Huang8Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, ChinaBackground. Many epidemiological studies have investigated the risk factors for clonorchiasis, but endoscopic findings of this disease in endoscopic retrograde cholangiopancreatography (ERCP) have not been well characterized. In this study, we evaluated clonorchiasis in ERCP in patients with biliary and pancreatic diseases. Methods. This was a retrospective two-center study in hospitalized patients who received ERCP between January 2012 and October 2018. All patients were divided into clonorchiasis and nonclonorchiasis groups. Data were analyzed using univariate analysis and multivariate analyses. Results. A total of 1119 patients were included, and clonorchiasis was diagnosed in 19.2% patients. Detection of Clonorchis sinensis eggs in bile samples was higher than that in fecal samples (85.9% vs. 58.7%; P=0.001). In multivariate analysis, male patients (95% confidence interval (CI): 1.945–4.249, P=0.0001), age≤60 years old (95% CI: 1.212–2.474, P=0.003), patients with papilla fistula (95% CI: 0.081–0.900, P=0.033), and patients with a common bile duct (CBD) diameter<12 mm (95% CI: 1.093–2.130, P=0.013) were associated with clonorchiasis incidence. Nonclonorchiasis endoscopic diagnosis did not significantly correlate with clonorchiasis incidence (P>0.05). Conclusions. The detection of C. sinensis eggs was significantly higher in bile than in fecal samples; thus, bile samples represent a preferable sample for the diagnosis of clonorchiasis in patients with biliary obstruction. We found that male, age≤60 years old, and CBD diameter<12 mm were independent risk factors for clonorchiasis, while papilla fistula was a protective factor.http://dx.doi.org/10.1155/2020/2946541 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guolin Liao Huaqiang Ruan Peng Peng Shiquan Liu Jianfu Qin Zhihai Liang Guodu Tang Mengbin Qin Jie’an Huang |
spellingShingle |
Guolin Liao Huaqiang Ruan Peng Peng Shiquan Liu Jianfu Qin Zhihai Liang Guodu Tang Mengbin Qin Jie’an Huang Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors BioMed Research International |
author_facet |
Guolin Liao Huaqiang Ruan Peng Peng Shiquan Liu Jianfu Qin Zhihai Liang Guodu Tang Mengbin Qin Jie’an Huang |
author_sort |
Guolin Liao |
title |
Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors |
title_short |
Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors |
title_full |
Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors |
title_fullStr |
Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors |
title_full_unstemmed |
Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors |
title_sort |
clonorchiasis in patients with biliary and pancreatic diseases: diagnosis and risk factors |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2020-01-01 |
description |
Background. Many epidemiological studies have investigated the risk factors for clonorchiasis, but endoscopic findings of this disease in endoscopic retrograde cholangiopancreatography (ERCP) have not been well characterized. In this study, we evaluated clonorchiasis in ERCP in patients with biliary and pancreatic diseases. Methods. This was a retrospective two-center study in hospitalized patients who received ERCP between January 2012 and October 2018. All patients were divided into clonorchiasis and nonclonorchiasis groups. Data were analyzed using univariate analysis and multivariate analyses. Results. A total of 1119 patients were included, and clonorchiasis was diagnosed in 19.2% patients. Detection of Clonorchis sinensis eggs in bile samples was higher than that in fecal samples (85.9% vs. 58.7%; P=0.001). In multivariate analysis, male patients (95% confidence interval (CI): 1.945–4.249, P=0.0001), age≤60 years old (95% CI: 1.212–2.474, P=0.003), patients with papilla fistula (95% CI: 0.081–0.900, P=0.033), and patients with a common bile duct (CBD) diameter<12 mm (95% CI: 1.093–2.130, P=0.013) were associated with clonorchiasis incidence. Nonclonorchiasis endoscopic diagnosis did not significantly correlate with clonorchiasis incidence (P>0.05). Conclusions. The detection of C. sinensis eggs was significantly higher in bile than in fecal samples; thus, bile samples represent a preferable sample for the diagnosis of clonorchiasis in patients with biliary obstruction. We found that male, age≤60 years old, and CBD diameter<12 mm were independent risk factors for clonorchiasis, while papilla fistula was a protective factor. |
url |
http://dx.doi.org/10.1155/2020/2946541 |
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