Illumination of PRRSV Cytotoxic T Lymphocyte Epitopes by the Three-Dimensional Structure and Peptidome of Swine Lymphocyte Antigen Class I (SLA-I)

Illumination of PRRSV Cytotoxic T Lymphocyte Epitopes by the Three-Dimensional Structure and Peptidome of Swine Lymphocyte Antigen Class I (SLA-I)

To investigate CTL epitope applications in swine, SLA-1*1502-restricted peptide epitopes matching porcine reproductive and respiratory syndrome virus (PRRSV) strains were explored by crystallography, biochemistry, and the specific pathogen-free (SPF) swine experiments. First, nine predicted PRRSV pe...

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Bibliographic Details
Main Authors: Xiaocheng Pan, Nianzhi Zhang, Xiaohui Wei, Yinan Jiang, Rong Chen, Qirun Li, Ruiying Liang, Lijie Zhang, Lizhen Ma, Chun Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
SLA
structure
CTL
epitope
PRRSV
vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02995/full

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