Is oral squamous cell carcinoma unique in terms of intra- and inter-tumoral heterogeneity?
Tumoral heterogeneity has become one of the important issues in cancer research and carries outmost weightage in designing personalized cancer medicine. Oral squamous cell carcinoma (OSCC) is present in unique microenvironment of oral cavity attributed to site-specific diversified tissue composition...
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doaj-07aaac3d169a426da9cffffcd62db8082020-11-25T03:19:26ZengSAGE PublishingTranslational Research in Oral Oncology2057-178X2017-04-01210.1177/2057178X17703578Is oral squamous cell carcinoma unique in terms of intra- and inter-tumoral heterogeneity?Gargi Sarode0Sachin C Sarode1Jagdish Tupkari2Shankargouda Patil3 Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Mumbai, Maharashtra, India Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi ArabiaTumoral heterogeneity has become one of the important issues in cancer research and carries outmost weightage in designing personalized cancer medicine. Oral squamous cell carcinoma (OSCC) is present in unique microenvironment of oral cavity attributed to site-specific diversified tissue compositions, microbial flora, diversified carcinogenic attacks, potentially malignant disorders, epithelial turnover rate, saliva, and closeness to external environment. Such microenvironment has potential to modulate the pathogenesis of many oral pathologies including OSCC. We believe that such factors and microenvironment are unique for OSCC and cannot be found in other carcinomas of the body. Methodologies such as multiregional sequencing, single-cell genomics, genomic landscape of bulk tumor sequencing, and so on, will help in understanding OSCC uniqueness in terms of heterogeneity. If explored, it will enable us to know the attributes of heterogeneity and their magnitude in OSCC, which will benefit in designing predictable biomarker and effective therapeutic strategy.https://doi.org/10.1177/2057178X17703578 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gargi Sarode Sachin C Sarode Jagdish Tupkari Shankargouda Patil |
spellingShingle |
Gargi Sarode Sachin C Sarode Jagdish Tupkari Shankargouda Patil Is oral squamous cell carcinoma unique in terms of intra- and inter-tumoral heterogeneity? Translational Research in Oral Oncology |
author_facet |
Gargi Sarode Sachin C Sarode Jagdish Tupkari Shankargouda Patil |
author_sort |
Gargi Sarode |
title |
Is oral squamous cell carcinoma unique in terms of intra- and inter-tumoral heterogeneity? |
title_short |
Is oral squamous cell carcinoma unique in terms of intra- and inter-tumoral heterogeneity? |
title_full |
Is oral squamous cell carcinoma unique in terms of intra- and inter-tumoral heterogeneity? |
title_fullStr |
Is oral squamous cell carcinoma unique in terms of intra- and inter-tumoral heterogeneity? |
title_full_unstemmed |
Is oral squamous cell carcinoma unique in terms of intra- and inter-tumoral heterogeneity? |
title_sort |
is oral squamous cell carcinoma unique in terms of intra- and inter-tumoral heterogeneity? |
publisher |
SAGE Publishing |
series |
Translational Research in Oral Oncology |
issn |
2057-178X |
publishDate |
2017-04-01 |
description |
Tumoral heterogeneity has become one of the important issues in cancer research and carries outmost weightage in designing personalized cancer medicine. Oral squamous cell carcinoma (OSCC) is present in unique microenvironment of oral cavity attributed to site-specific diversified tissue compositions, microbial flora, diversified carcinogenic attacks, potentially malignant disorders, epithelial turnover rate, saliva, and closeness to external environment. Such microenvironment has potential to modulate the pathogenesis of many oral pathologies including OSCC. We believe that such factors and microenvironment are unique for OSCC and cannot be found in other carcinomas of the body. Methodologies such as multiregional sequencing, single-cell genomics, genomic landscape of bulk tumor sequencing, and so on, will help in understanding OSCC uniqueness in terms of heterogeneity. If explored, it will enable us to know the attributes of heterogeneity and their magnitude in OSCC, which will benefit in designing predictable biomarker and effective therapeutic strategy. |
url |
https://doi.org/10.1177/2057178X17703578 |
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