Adiponectin Deficiency Triggers Bone Loss by Up-Regulation of Osteoclastogenesis and Down-Regulation of Osteoblastogenesis

Adiponectin Deficiency Triggers Bone Loss by Up-Regulation of Osteoclastogenesis and Down-Regulation of Osteoblastogenesis

Osteoporosis and bone disorders related to the metabolic syndrome are often associated with adipokines secreted by adipocytes in bone. Adiponectin, a type of adipokine, is a regulator of immune responses and metabolic processes, but its role in bone biology remains uncertain. We investigated the rol...

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Bibliographic Details
Main Authors: Jihyun Yang, Ok-Jin Park, Jiseon Kim, Sora Han, Young Yang, Cheol-Heui Yun, Seung Hyun Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Endocrinology
Subjects:
adiponectin
osteoclast
osteoblast
adipocyte
RANKL/OPG ratio
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00815/full

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