In-Silico Analysis of the BDNF (Brain Derived Neurotrophic Factor) Protein of Pigeon (Columba livia)

• Main Authors: Ni Gusti Ayu Galuh Candra Kirana, I Made Budiarsa, I Nengah Kundera, Mohammad Jamhari
• Format: Article
• Language: Indonesian
• Published: Universitas Sultan Ageng Tirtayasa 2020-01-01
• Series: EduChemia
• Subjects: bdnf; three dimensional of protein; homology
• Online Access: https://jurnal.untirta.ac.id/index.php/EduChemia/article/view/6763
• ISSN: 2502-4779; 2502-4787

<p><span lang="IN">BDNF protein plays a role in the growth and survival of neurons. BDNF protein has some uniqueness</span><span lang="EN-US">,</span><span lang="IN"> and information on this protein is still limited reported</span><span lang="EN-US">, </span><span lang="IN">especially in pigeons. The purpose of this study is to predict the three-dimensional structure of the </span><span lang="EN-US">pigeon of </span><span lang="IN"> BDNF protein, to provide information in understanding the characteristics, structure of the protein using a homology approach through in-silico analysis. The BDNF protein is predicted using the SWISS-MODEL server and visualizing the prediction results on the CHIMERA Software. Pigeon BDNF protein was taken from Uniprot with </span><span lang="EN-US">a </span><span lang="IN">B4Z8Q access code</span><span lang="IN">with a template of 1b8m.</span><span lang="EN-US">1. </span><span lang="IN">The analysis shows that BDNF protein </span><span lang="EN-US">has </span><span lang="IN"> an identity of 93,20% consisting of 226 amino acids with a target QMEAN value of -0.17 and hydrophobic amino acids namely Trp, His, Tyr, Ile, Leu, Gly, Lys, Cys, Ala, Phe, Met, and Val. Carboxyl residues</span><span lang="EN-US">,</span><span lang="IN"> namely Glu, Asp and Val, and amine residues</span><span lang="EN-US">,</span><span lang="IN"> namely Lys and Ser, with 82 hydrogen bonds.</span></p>