The Chinese Herb Codonopsis pilosula Isolate Isorhapontigenin protects against oxidative stress injury by inhibiting the activation of PI3K/Akt signaling pathway

• Main Author: Youquan Gu, Tianhong Wang, Jun Chen, Zhe Zhou, Ying Wang, Jiangjun Chen, Ning Liu, Zhenxiu Jiang
• Format: Article
• Language: English
• Published: IMR (Innovative Medical Research) Press Limited 2020-06-01
• Series: Journal of Integrative Neuroscience
• Subjects: |isorhapontigenin|oxidative stress|parkinson's disease|pi3k/akt signaling pathway|traditional chinese medicine|codonopsis pilosula
• Online Access: https://jin.imrpress.com/fileup/1757-448X/PDF/1593409406462-113193428.pdf

We investigated the effects of the Chinese herb Codonopsis pilosula isolate isorhapontigenin on antioxidant factor and the PI3K/Serine/Akt signaling pathway in Parkinson's disease. This research was, therefore, carried out to explore a possible protective mechanism of isorhamnetin in Parkinson's disease. The results support that isorhapontigenin could effectively inhibit isorhapontigenin restored myeloperoxidase + induced reduction of antioxidant levels. Also, 1-Methyl-4-phenylpyridine up-regulated the expression of phosphorylated-Akt, phosphorylated-PI3K, and phosphorylated mammalian target of rapamycin, while isorhapontigenin inhibited the expression of phosphorylated-Akt, phosphorylated-PI3K, and phosphorylated- mammalian target of rapamycin. Furthermore, LY294002 improved the antioxidant effect of isorhapontigenin in PC12 cells, and insulin-like growth factor 1 inhibited the antioxidant effect of isorhapontigenin in PC12 cells. Our results support the finding that isorhamnetin enhanced the antioxidant effect induced by 1-Methyl-4-phenylpyridine in PC12 cells by suppressing the activation of the PI3K/Akt signaling pathway.