Diminished white matter integrity in patients with systemic lupus erythematosus
Purpose: Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25–70% of patients. Using diffusion tensor imaging (DTI) various studies have reported changes in white matter integrity in SLE p...
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doaj-07c99708b625441aa3166077d9478d5b2020-11-24T22:34:41ZengElsevierNeuroImage: Clinical2213-15822014-01-015C29129710.1016/j.nicl.2014.07.001Diminished white matter integrity in patients with systemic lupus erythematosusTobias Schmidt-Wilcke0Patricia Cagnoli1Page Wang2Thomas Schultz3Anne Lotz4William J. Mccune5Pia C. Sundgren6Department of Neurology, Berufsgenossenschaftliche Universitätsklinik, Ruhr Universität Bochum, Bochum, GermanyDepartment of Rheumatology, University of Michigan, Ann Arbor, MI, USADepartment of Diagnostic Radiology, University of Michigan Hospital, Ann Arbor, USAMax Planck Institute for Intelligent Systems, Tübingen, GermanyInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr Universität Bochum, Bochum, GermanyDepartment of Rheumatology, University of Michigan, Ann Arbor, MI, USADepartment of Diagnostic Radiology, University of Michigan Hospital, Ann Arbor, USA Purpose: Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25–70% of patients. Using diffusion tensor imaging (DTI) various studies have reported changes in white matter integrity in SLE patients with neuropsychiatric symptoms (NPSLE patients). The purpose of this study was to investigate, if regional changes in white matter integrity can also be detected in SLE patients without neuropsychiatric symptoms (non-NPSLE patients). Methods: Applying DTI and tract based spatial statistics (TBSS) we investigated 19 NPSLE patients, 19 non-NPSLE and 18 healthy controls. Groups were matched for age and sex. Image pre-processing was performed using FSL, following the TBSS pipeline (eddy current correction, estimation of fractional anisotropy (FA), normalization, skeletonization of the group mean FA image). A general linear model with threshold-free cluster enhancement was used to assess significant differences between the three groups. Results: Statistical analyses revealed several regions of decreased prefrontal white matter integrity (decreased FA) in both groups of SLE patients. The changes found in the non-NPSLE patients (as compared to healthy controls) overlapped with those in the NPSLE patients, but were not as pronounced. Conclusions: Our data suggest that changes in regional white matter integrity, in terms of a decrease in FA, are present not only in NPSLE patients, but also in non-NPSLE patients, though to a lesser degree. We also demonstrate that the way statistical maps are corrected for multiple comparisons has a profound influence on whether alterations in white matter integrity in non-NPSLE patients are deemed significant. http://www.sciencedirect.com/science/article/pii/S2213158214000916Systemic lupus erythematosusDiffusion tensor imagingWhite matter |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tobias Schmidt-Wilcke Patricia Cagnoli Page Wang Thomas Schultz Anne Lotz William J. Mccune Pia C. Sundgren |
spellingShingle |
Tobias Schmidt-Wilcke Patricia Cagnoli Page Wang Thomas Schultz Anne Lotz William J. Mccune Pia C. Sundgren Diminished white matter integrity in patients with systemic lupus erythematosus NeuroImage: Clinical Systemic lupus erythematosus Diffusion tensor imaging White matter |
author_facet |
Tobias Schmidt-Wilcke Patricia Cagnoli Page Wang Thomas Schultz Anne Lotz William J. Mccune Pia C. Sundgren |
author_sort |
Tobias Schmidt-Wilcke |
title |
Diminished white matter integrity in patients with systemic lupus erythematosus |
title_short |
Diminished white matter integrity in patients with systemic lupus erythematosus |
title_full |
Diminished white matter integrity in patients with systemic lupus erythematosus |
title_fullStr |
Diminished white matter integrity in patients with systemic lupus erythematosus |
title_full_unstemmed |
Diminished white matter integrity in patients with systemic lupus erythematosus |
title_sort |
diminished white matter integrity in patients with systemic lupus erythematosus |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2014-01-01 |
description |
Purpose: Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25–70% of patients. Using diffusion tensor imaging (DTI) various studies have reported changes in white matter integrity in SLE patients with neuropsychiatric symptoms (NPSLE patients). The purpose of this study was to investigate, if regional changes in white matter integrity can also be detected in SLE patients without neuropsychiatric symptoms (non-NPSLE patients).
Methods: Applying DTI and tract based spatial statistics (TBSS) we investigated 19 NPSLE patients, 19 non-NPSLE and 18 healthy controls. Groups were matched for age and sex. Image pre-processing was performed using FSL, following the TBSS pipeline (eddy current correction, estimation of fractional anisotropy (FA), normalization, skeletonization of the group mean FA image). A general linear model with threshold-free cluster enhancement was used to assess significant differences between the three groups.
Results: Statistical analyses revealed several regions of decreased prefrontal white matter integrity (decreased FA) in both groups of SLE patients. The changes found in the non-NPSLE patients (as compared to healthy controls) overlapped with those in the NPSLE patients, but were not as pronounced.
Conclusions: Our data suggest that changes in regional white matter integrity, in terms of a decrease in FA, are present not only in NPSLE patients, but also in non-NPSLE patients, though to a lesser degree. We also demonstrate that the way statistical maps are corrected for multiple comparisons has a profound influence on whether alterations in white matter integrity in non-NPSLE patients are deemed significant.
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topic |
Systemic lupus erythematosus Diffusion tensor imaging White matter |
url |
http://www.sciencedirect.com/science/article/pii/S2213158214000916 |
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