Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice
Aging has become a primary cause of chronic kidney diseases, which ultimately progress to renal interstitial fibrosis. Endoplasmic reticulum (ER) stress has been reported to participate in tubular epithelial cells injury. Ginsenoside Rg1 may have protective effects on kidney aging. In this study, we...
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doaj-07cb2101863b44ee83756fb1f9c676d12021-04-30T07:19:12ZengElsevierJournal of Functional Foods1756-46462020-09-0172104049Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 miceShixin Ding0Han Zhang1Zhenghao Sun2Yuli Han3Yan Li4Xianan Dong5Yanyan Yin6Weiping Li7Weizu Li8Department of Pharmacology, Basic Medicine College, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, ChinaDepartment of Pharmacology, Basic Medicine College, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, ChinaDepartment of Pharmacology, Basic Medicine College, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, ChinaDepartment of Pharmacology, Basic Medicine College, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, ChinaDepartment of Pharmacology, Basic Medicine College, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, ChinaDepartment of Pharmacology, Basic Medicine College, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, ChinaDepartment of Pharmacology, Basic Medicine College, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, ChinaDepartment of Pharmacology, Basic Medicine College, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Anqing Medical and Pharmaceutical College, Anqing 246052, Anhui, China; Corresponding authors at: Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei 230032, China (W. Li).Department of Pharmacology, Basic Medicine College, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Corresponding authors at: Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei 230032, China (W. Li).Aging has become a primary cause of chronic kidney diseases, which ultimately progress to renal interstitial fibrosis. Endoplasmic reticulum (ER) stress has been reported to participate in tubular epithelial cells injury. Ginsenoside Rg1 may have protective effects on kidney aging. In this study, we investigated the tubular interstitial fibrosis and ER stress change in aged mice, and further observed the effects of Rg1 on renal interstitial fibrosis and ER stress in SAMP8 mice. The results demonstrated that the ER stress, apoptosis and interstitial fibrosis were significantly increased in the tubular epithelial cells in 20-month-old (M) and 24M mice. Meanwhile, we found that Rg1 significantly attenuated the tubular epithelial cells ER stress, apoptosis and interstitial fibrosis in SAMP8 mice. This study suggested that ER stress and apoptosis were closely implicated with aging-related renal interstitial fibrosis in aging progression. Rg1 could ameliorate aging-related renal interstitial fibrosis via inhibiting ER stress and apoptosis.http://www.sciencedirect.com/science/article/pii/S1756464620302735ginsenoside Rg1Endoplasmic reticulum stressRenal tubular epithelial cellsApoptosisRenal interstitial fibrosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shixin Ding Han Zhang Zhenghao Sun Yuli Han Yan Li Xianan Dong Yanyan Yin Weiping Li Weizu Li |
spellingShingle |
Shixin Ding Han Zhang Zhenghao Sun Yuli Han Yan Li Xianan Dong Yanyan Yin Weiping Li Weizu Li Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice Journal of Functional Foods ginsenoside Rg1 Endoplasmic reticulum stress Renal tubular epithelial cells Apoptosis Renal interstitial fibrosis |
author_facet |
Shixin Ding Han Zhang Zhenghao Sun Yuli Han Yan Li Xianan Dong Yanyan Yin Weiping Li Weizu Li |
author_sort |
Shixin Ding |
title |
Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice |
title_short |
Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice |
title_full |
Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice |
title_fullStr |
Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice |
title_full_unstemmed |
Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice |
title_sort |
ginsenoside rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in samp8 mice |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2020-09-01 |
description |
Aging has become a primary cause of chronic kidney diseases, which ultimately progress to renal interstitial fibrosis. Endoplasmic reticulum (ER) stress has been reported to participate in tubular epithelial cells injury. Ginsenoside Rg1 may have protective effects on kidney aging. In this study, we investigated the tubular interstitial fibrosis and ER stress change in aged mice, and further observed the effects of Rg1 on renal interstitial fibrosis and ER stress in SAMP8 mice. The results demonstrated that the ER stress, apoptosis and interstitial fibrosis were significantly increased in the tubular epithelial cells in 20-month-old (M) and 24M mice. Meanwhile, we found that Rg1 significantly attenuated the tubular epithelial cells ER stress, apoptosis and interstitial fibrosis in SAMP8 mice. This study suggested that ER stress and apoptosis were closely implicated with aging-related renal interstitial fibrosis in aging progression. Rg1 could ameliorate aging-related renal interstitial fibrosis via inhibiting ER stress and apoptosis. |
topic |
ginsenoside Rg1 Endoplasmic reticulum stress Renal tubular epithelial cells Apoptosis Renal interstitial fibrosis |
url |
http://www.sciencedirect.com/science/article/pii/S1756464620302735 |
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