Nanoemulsions produced with varied type of emulsifier and oil content: An influence of formulation and process parameters on the characteristics and physical stability
The aim of the present study was to prepare oil-in-water nanoemulsions stabilized with a novel natural alkyl polyglucoside surfactant and to compare them with corresponding lecithin/polysorbate 80 - based nanoemulsions in terms of physicochemical properties and physical stability. Nanoemuls...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Association of Chemical Engineers of Serbia
2013-01-01
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Series: | Hemijska Industrija |
Subjects: | |
Online Access: | http://www.doiserbia.nb.rs/img/doi/0367-598X/2013/0367-598X1300005D.pdf |
Summary: | The aim of the present study was to prepare oil-in-water nanoemulsions
stabilized with a novel natural alkyl polyglucoside surfactant and to compare
them with corresponding lecithin/polysorbate 80 - based nanoemulsions in
terms of physicochemical properties and physical stability. Nanoemulsions
were prepared by high pressure homogenization, using 20, 30 and 40% (w/w)
medium chain triglyceride as oil phase, and 4, 6 and 8% (w/w)
lecithin/polysorbate 80 mixture (1/1) or caprylyl/capryl glucoside as
emulsifiers. The influence of emulsifier type, emulsifier concentration and
oil content was investigated with respect to changes in particle size,
particle size distribution, surface charge and physical stability. The
influence of production parameters (number of homogenization cycles, type of
homogenization process, homogenization pressure) on particle size was also
investigated. Analysis was performed by photon correlation spectroscopy,
laser diffraction, zeta potential, pH and electrical conductivity
measurements. All formulations produced revealed a small droplet size ranging
from 147 to 228 nm and a very narrow size distribution (polydispersity index
range 0,072-0,124). Zeta potentials were about -20 mV and -50 mV for
nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl
glucoside, respectively. The results obtained during the stability studies (6
months at 25°C and 1 month at 40°C) indicated that nanoemulsion stability was
influenced by their composition. Acquired results also suggested the most
appropriate production parameters: 9 homogenization cycles, homogenization
pressure of 500 bar and discontinuous process of homogenization. |
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ISSN: | 0367-598X 2217-7426 |