Nanoemulsions produced with varied type of emulsifier and oil content: An influence of formulation and process parameters on the characteristics and physical stability
The aim of the present study was to prepare oil-in-water nanoemulsions stabilized with a novel natural alkyl polyglucoside surfactant and to compare them with corresponding lecithin/polysorbate 80 - based nanoemulsions in terms of physicochemical properties and physical stability. Nanoemuls...
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doaj-07d8e33029104cd0b725e1d9f9d44c5f2020-11-24T23:43:35ZengAssociation of Chemical Engineers of SerbiaHemijska Industrija 0367-598X2217-74262013-01-0167579580910.2298/HEMIND120905005D0367-598X1300005DNanoemulsions produced with varied type of emulsifier and oil content: An influence of formulation and process parameters on the characteristics and physical stabilityĐorđević Sanela M.0Cekić Nebojša D.1Isailović Tanja M.2Milić Jela R.3Vuleta Gordana M.4Lazić Miodrag L.5Savić Snežana D.6Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, BelgradeFaculty of Technology, LeskovacFaculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, BelgradeFaculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, BelgradeFaculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, BelgradeFaculty of Technology, LeskovacFaculty of Technology, LeskovacThe aim of the present study was to prepare oil-in-water nanoemulsions stabilized with a novel natural alkyl polyglucoside surfactant and to compare them with corresponding lecithin/polysorbate 80 - based nanoemulsions in terms of physicochemical properties and physical stability. Nanoemulsions were prepared by high pressure homogenization, using 20, 30 and 40% (w/w) medium chain triglyceride as oil phase, and 4, 6 and 8% (w/w) lecithin/polysorbate 80 mixture (1/1) or caprylyl/capryl glucoside as emulsifiers. The influence of emulsifier type, emulsifier concentration and oil content was investigated with respect to changes in particle size, particle size distribution, surface charge and physical stability. The influence of production parameters (number of homogenization cycles, type of homogenization process, homogenization pressure) on particle size was also investigated. Analysis was performed by photon correlation spectroscopy, laser diffraction, zeta potential, pH and electrical conductivity measurements. All formulations produced revealed a small droplet size ranging from 147 to 228 nm and a very narrow size distribution (polydispersity index range 0,072-0,124). Zeta potentials were about -20 mV and -50 mV for nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl glucoside, respectively. The results obtained during the stability studies (6 months at 25°C and 1 month at 40°C) indicated that nanoemulsion stability was influenced by their composition. Acquired results also suggested the most appropriate production parameters: 9 homogenization cycles, homogenization pressure of 500 bar and discontinuous process of homogenization.http://www.doiserbia.nb.rs/img/doi/0367-598X/2013/0367-598X1300005D.pdfnanoemulsioncaprylyl/capryl glucosidelecithinpolysorbate 80high pressure homogenizationphysical stability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Đorđević Sanela M. Cekić Nebojša D. Isailović Tanja M. Milić Jela R. Vuleta Gordana M. Lazić Miodrag L. Savić Snežana D. |
spellingShingle |
Đorđević Sanela M. Cekić Nebojša D. Isailović Tanja M. Milić Jela R. Vuleta Gordana M. Lazić Miodrag L. Savić Snežana D. Nanoemulsions produced with varied type of emulsifier and oil content: An influence of formulation and process parameters on the characteristics and physical stability Hemijska Industrija nanoemulsion caprylyl/capryl glucoside lecithin polysorbate 80 high pressure homogenization physical stability |
author_facet |
Đorđević Sanela M. Cekić Nebojša D. Isailović Tanja M. Milić Jela R. Vuleta Gordana M. Lazić Miodrag L. Savić Snežana D. |
author_sort |
Đorđević Sanela M. |
title |
Nanoemulsions produced with varied type of emulsifier and oil content: An influence of formulation and process parameters on the characteristics and physical stability |
title_short |
Nanoemulsions produced with varied type of emulsifier and oil content: An influence of formulation and process parameters on the characteristics and physical stability |
title_full |
Nanoemulsions produced with varied type of emulsifier and oil content: An influence of formulation and process parameters on the characteristics and physical stability |
title_fullStr |
Nanoemulsions produced with varied type of emulsifier and oil content: An influence of formulation and process parameters on the characteristics and physical stability |
title_full_unstemmed |
Nanoemulsions produced with varied type of emulsifier and oil content: An influence of formulation and process parameters on the characteristics and physical stability |
title_sort |
nanoemulsions produced with varied type of emulsifier and oil content: an influence of formulation and process parameters on the characteristics and physical stability |
publisher |
Association of Chemical Engineers of Serbia |
series |
Hemijska Industrija |
issn |
0367-598X 2217-7426 |
publishDate |
2013-01-01 |
description |
The aim of the present study was to prepare oil-in-water nanoemulsions
stabilized with a novel natural alkyl polyglucoside surfactant and to compare
them with corresponding lecithin/polysorbate 80 - based nanoemulsions in
terms of physicochemical properties and physical stability. Nanoemulsions
were prepared by high pressure homogenization, using 20, 30 and 40% (w/w)
medium chain triglyceride as oil phase, and 4, 6 and 8% (w/w)
lecithin/polysorbate 80 mixture (1/1) or caprylyl/capryl glucoside as
emulsifiers. The influence of emulsifier type, emulsifier concentration and
oil content was investigated with respect to changes in particle size,
particle size distribution, surface charge and physical stability. The
influence of production parameters (number of homogenization cycles, type of
homogenization process, homogenization pressure) on particle size was also
investigated. Analysis was performed by photon correlation spectroscopy,
laser diffraction, zeta potential, pH and electrical conductivity
measurements. All formulations produced revealed a small droplet size ranging
from 147 to 228 nm and a very narrow size distribution (polydispersity index
range 0,072-0,124). Zeta potentials were about -20 mV and -50 mV for
nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl
glucoside, respectively. The results obtained during the stability studies (6
months at 25°C and 1 month at 40°C) indicated that nanoemulsion stability was
influenced by their composition. Acquired results also suggested the most
appropriate production parameters: 9 homogenization cycles, homogenization
pressure of 500 bar and discontinuous process of homogenization. |
topic |
nanoemulsion caprylyl/capryl glucoside lecithin polysorbate 80 high pressure homogenization physical stability |
url |
http://www.doiserbia.nb.rs/img/doi/0367-598X/2013/0367-598X1300005D.pdf |
work_keys_str_mv |
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