Multirate delivery of multiple therapeutic agents from metal-organic frameworks

Multirate delivery of multiple therapeutic agents from metal-organic frameworks

The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule,...

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Bibliographic Details
Main Authors: Alistair C. McKinlay, Phoebe K. Allan, Catherine L. Renouf, Morven J. Duncan, Paul S. Wheatley, Stewart J. Warrender, Daniel Dawson, Sharon E. Ashbrook, Barbara Gil, Bartosz Marszalek, Tina Düren, Jennifer J. Williams, Cedric Charrier, Derry K. Mercer, Simon J. Teat, Russell E. Morris
Format: Article
Language:English
Published: AIP Publishing LLC 2014-12-01
Series:APL Materials
Online Access:http://dx.doi.org/10.1063/1.4903290
Description
Summary:The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.
ISSN:2166-532X

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