Multirate delivery of multiple therapeutic agents from metal-organic frameworks
The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule,...
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2014-12-01
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| Series: | APL Materials |
| Online Access: | http://dx.doi.org/10.1063/1.4903290 |
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doaj-07d8ecfef54849baa0a77572f3f5d7b62020-11-24T22:18:43ZengAIP Publishing LLCAPL Materials2166-532X2014-12-01212124108124108-810.1063/1.4903290010494APMMultirate delivery of multiple therapeutic agents from metal-organic frameworksAlistair C. McKinlay0Phoebe K. Allan1Catherine L. Renouf2Morven J. Duncan3Paul S. Wheatley4Stewart J. Warrender5Daniel Dawson6Sharon E. Ashbrook7Barbara Gil8Bartosz Marszalek9Tina Düren10Jennifer J. Williams11Cedric Charrier12Derry K. Mercer13Simon J. Teat14Russell E. Morris15EaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United KingdomEaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United KingdomEaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United KingdomEaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United KingdomEaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United KingdomEaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United KingdomEaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United KingdomEaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United KingdomFaculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, PolandFaculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, PolandSchool of Engineering, Institute for Materials and Processes, The University of Edinburgh, Edinburgh EH9 3JL, United KingdomSchool of Engineering, Institute for Materials and Processes, The University of Edinburgh, Edinburgh EH9 3JL, United KingdomNovaBiotics Ltd., Cruickshank Building, Craibstone, Aberdeen AB21 9TR, United KingdomNovaBiotics Ltd., Cruickshank Building, Craibstone, Aberdeen AB21 9TR, United KingdomAdvanced Light Source, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 15-317, Berkeley, California 94720, USAEaStCHEM School of Chemistry, University of St Andrews, St Andrews KY16 9ST, United Kingdom The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria. http://dx.doi.org/10.1063/1.4903290 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alistair C. McKinlay Phoebe K. Allan Catherine L. Renouf Morven J. Duncan Paul S. Wheatley Stewart J. Warrender Daniel Dawson Sharon E. Ashbrook Barbara Gil Bartosz Marszalek Tina Düren Jennifer J. Williams Cedric Charrier Derry K. Mercer Simon J. Teat Russell E. Morris |
| spellingShingle |
Alistair C. McKinlay Phoebe K. Allan Catherine L. Renouf Morven J. Duncan Paul S. Wheatley Stewart J. Warrender Daniel Dawson Sharon E. Ashbrook Barbara Gil Bartosz Marszalek Tina Düren Jennifer J. Williams Cedric Charrier Derry K. Mercer Simon J. Teat Russell E. Morris Multirate delivery of multiple therapeutic agents from metal-organic frameworks APL Materials |
| author_facet |
Alistair C. McKinlay Phoebe K. Allan Catherine L. Renouf Morven J. Duncan Paul S. Wheatley Stewart J. Warrender Daniel Dawson Sharon E. Ashbrook Barbara Gil Bartosz Marszalek Tina Düren Jennifer J. Williams Cedric Charrier Derry K. Mercer Simon J. Teat Russell E. Morris |
| author_sort |
Alistair C. McKinlay |
| title |
Multirate delivery of multiple therapeutic agents from metal-organic frameworks |
| title_short |
Multirate delivery of multiple therapeutic agents from metal-organic frameworks |
| title_full |
Multirate delivery of multiple therapeutic agents from metal-organic frameworks |
| title_fullStr |
Multirate delivery of multiple therapeutic agents from metal-organic frameworks |
| title_full_unstemmed |
Multirate delivery of multiple therapeutic agents from metal-organic frameworks |
| title_sort |
multirate delivery of multiple therapeutic agents from metal-organic frameworks |
| publisher |
AIP Publishing LLC |
| series |
APL Materials |
| issn |
2166-532X |
| publishDate |
2014-12-01 |
| description |
The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.
|
| url |
http://dx.doi.org/10.1063/1.4903290 |
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