Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination

Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination

Effective priming and activation of tumor-specific CD8+ cytotoxic T lymphocytes (CTLs) is crucial for realizing the potential of therapeutic cancer vaccination. This requires cytosolic antigens that feed into the MHC class I presentation pathway, which is not efficiently achieved with most current v...

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Bibliographic Details
Main Authors: Markus Haug, Gaute Brede, Monika Håkerud, Anne Grete Nedberg, Odrun A. Gederaas, Trude H. Flo, Victoria T. Edwards, Pål K. Selbo, Anders Høgset, Øyvind Halaas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
therapeutic tumor vaccination
peptide vaccination
CD8+ cytotoxic T cells
MHC class I antigen presentation
cross-presentation
adjuvant effect
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00650/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00650/full

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