Genital Involvement In Pre-Pubertal Pediatric Population: A Rare Aspect of Crohn’s Disease

• Main Authors: Qurratul Ann Warsi, Meghana Kunduru, Manoochehr Karjoo, Mirza Beg
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2016-09-01
• Series: International Journal of Pediatrics
• Subjects: Crohn’s disease (CD); Inflammatory Bowel Disease (IBD); Infliximab; Tumor necrosis factor alpha (TNF-α); Vulvar swelling
• Online Access: http://ijp.mums.ac.ir/article_7334_c0c47553429c0959e420da970cf1667c.pdf
• ISSN: 2345-5047; 2345-5055

Crohn’s disease is an inflammatory bowel disease (IBD), characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. Environmental triggers and interaction of genetic determinants also play an indispensible role. In this case report, we present a pre-pubertal girl with intermittent and refractory genital swelling. We emphasize that Crohn’s disease must be considered in the differential diagnosis of recurrent, non-tender, erythematous and edematous lesions of the genital area. We conclude with future directions for diagnosing and managing vulvar Crohn’s disease in pediatric population.