Gut Microbiome Structure and Association with Host Factors in a Korean Population
ABSTRACT Characterizing the gut microbiome in the healthy population is the first step in elucidating its associations with host health conditions. Populations with different diet patterns, lifestyles, and genetic backgrounds harbor different gut microbes. In this study, we characterized the gut mic...
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doaj-07e1ecd91c584525a1321d1f5c83ef552021-08-31T13:57:56ZengAmerican Society for MicrobiologymSystems2379-50772021-08-016410.1128/mSystems.00179-21Gut Microbiome Structure and Association with Host Factors in a Korean PopulationMi Young Lim0Seungpyo Hong1So-Jung Bang2Won-Hyong Chung3Ji-Hee Shin4Jung-Ha Kim5Young-Do Nam6Research Group of Healthcare, Research Division of Food Functionality, Korea Food Research Institute, Jeollabuk-do, Republic of KoreaResearch Group of Healthcare, Research Division of Food Functionality, Korea Food Research Institute, Jeollabuk-do, Republic of KoreaGraduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Gyeonggi-do, Republic of KoreaResearch Group of Healthcare, Research Division of Food Functionality, Korea Food Research Institute, Jeollabuk-do, Republic of KoreaResearch Group of Healthcare, Research Division of Food Functionality, Korea Food Research Institute, Jeollabuk-do, Republic of KoreaDepartment of Family Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of KoreaResearch Group of Healthcare, Research Division of Food Functionality, Korea Food Research Institute, Jeollabuk-do, Republic of KoreaABSTRACT Characterizing the gut microbiome in the healthy population is the first step in elucidating its associations with host health conditions. Populations with different diet patterns, lifestyles, and genetic backgrounds harbor different gut microbes. In this study, we characterized the gut microbiome of 890 healthy Koreans using 16S rRNA sequencing. The Korean population harbored a relatively large fraction of the Prevotella enterotype and presented a distinctive gut microbiome, compared to that in the populations of other countries. Additionally, we determined the clusters of cooccurring microbes that were quantitatively correlated with each other. We found that microbe composition of the gut was strongly associated with age. We identified that the abundance of members of Bacteroidia and Clostridia differed with the host dietary patterns, body mass index, and stool frequency. The gut microbiome data obtained in this study would be an important resource for future studies addressing microbial contributions in health and disease. IMPORTANCE Comparing the gut microbiomes of healthy controls and disease patients showed that the composition of the gut microbiome is associated with various host health conditions. The gut microbiome in healthy Western populations is well characterized, while that of non-Western populations, with different diet patterns, lifestyles, and genetic backgrounds, is not clearly defined. In this study, we characterized the microbiome of 890 healthy Korean individuals using 16S rRNA sequencing and found that Koreans have a gut microbiome different from that in the individuals of neighboring countries. The members of Bacteroidetes and Firmicutes cooccurred and were quantitatively associated with each other. Additionally, we found that the gut microbial composition is strongly associated with the host’s age. The microbiome data presented here represent the gut microbiome of a healthy Korean population and could be used to unveil gut microbiome-associated host conditions in this population.https://journals.asm.org/doi/10.1128/mSystems.00179-21dietary patternenterotypegut microbiomehost factorhost-microbiomemicrobial cluster |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mi Young Lim Seungpyo Hong So-Jung Bang Won-Hyong Chung Ji-Hee Shin Jung-Ha Kim Young-Do Nam |
spellingShingle |
Mi Young Lim Seungpyo Hong So-Jung Bang Won-Hyong Chung Ji-Hee Shin Jung-Ha Kim Young-Do Nam Gut Microbiome Structure and Association with Host Factors in a Korean Population mSystems dietary pattern enterotype gut microbiome host factor host-microbiome microbial cluster |
author_facet |
Mi Young Lim Seungpyo Hong So-Jung Bang Won-Hyong Chung Ji-Hee Shin Jung-Ha Kim Young-Do Nam |
author_sort |
Mi Young Lim |
title |
Gut Microbiome Structure and Association with Host Factors in a Korean Population |
title_short |
Gut Microbiome Structure and Association with Host Factors in a Korean Population |
title_full |
Gut Microbiome Structure and Association with Host Factors in a Korean Population |
title_fullStr |
Gut Microbiome Structure and Association with Host Factors in a Korean Population |
title_full_unstemmed |
Gut Microbiome Structure and Association with Host Factors in a Korean Population |
title_sort |
gut microbiome structure and association with host factors in a korean population |
publisher |
American Society for Microbiology |
series |
mSystems |
issn |
2379-5077 |
publishDate |
2021-08-01 |
description |
ABSTRACT Characterizing the gut microbiome in the healthy population is the first step in elucidating its associations with host health conditions. Populations with different diet patterns, lifestyles, and genetic backgrounds harbor different gut microbes. In this study, we characterized the gut microbiome of 890 healthy Koreans using 16S rRNA sequencing. The Korean population harbored a relatively large fraction of the Prevotella enterotype and presented a distinctive gut microbiome, compared to that in the populations of other countries. Additionally, we determined the clusters of cooccurring microbes that were quantitatively correlated with each other. We found that microbe composition of the gut was strongly associated with age. We identified that the abundance of members of Bacteroidia and Clostridia differed with the host dietary patterns, body mass index, and stool frequency. The gut microbiome data obtained in this study would be an important resource for future studies addressing microbial contributions in health and disease. IMPORTANCE Comparing the gut microbiomes of healthy controls and disease patients showed that the composition of the gut microbiome is associated with various host health conditions. The gut microbiome in healthy Western populations is well characterized, while that of non-Western populations, with different diet patterns, lifestyles, and genetic backgrounds, is not clearly defined. In this study, we characterized the microbiome of 890 healthy Korean individuals using 16S rRNA sequencing and found that Koreans have a gut microbiome different from that in the individuals of neighboring countries. The members of Bacteroidetes and Firmicutes cooccurred and were quantitatively associated with each other. Additionally, we found that the gut microbial composition is strongly associated with the host’s age. The microbiome data presented here represent the gut microbiome of a healthy Korean population and could be used to unveil gut microbiome-associated host conditions in this population. |
topic |
dietary pattern enterotype gut microbiome host factor host-microbiome microbial cluster |
url |
https://journals.asm.org/doi/10.1128/mSystems.00179-21 |
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