EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis

EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis

Abstract Forkhead‐Box Class O 4 (FOXO4) is involved in critical biological functions, but its response to EGF‐PKB/Akt signal regulation is not well characterized. Here, it is reported that FOXO4 levels are downregulated in response to EGF treatment, with concurrent elevation of COP9 Signalosome subu...

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Bibliographic Details
Main Authors: Hyun Ho Choi, Shaomin Zou, Jian‐lin Wu, Huashe Wang, Liem Phan, Kai Li, Peng Zhang, Daici Chen, Qingxin Liu, Baifu Qin, Thu Anh Thai Nguyen, Sai‐Ching J. Yeung, Lekun Fang, Mong‐Hong Lee
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Advanced Science
Subjects:
COP1
COP9
CSN
FOXO4
SGOC
Online Access:https://doi.org/10.1002/advs.202000681

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