Current concepts of salivary gland tumors
The embryonic development of salivary glands is a complex process that creates compact, highly organized secretory organs with functions essential for oral health. The development is an example of branching morphogenesis, recent research found to involve unexpectedly dynamic cell motility, and novel...
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Wolters Kluwer Medknow Publications
2015-01-01
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doaj-07e2dd3a3e8746168e79a529ea4718112020-11-24T21:29:46ZengWolters Kluwer Medknow PublicationsJournal of Orofacial Sciences0975-88442015-01-0172767910.4103/0975-8844.169751Current concepts of salivary gland tumorsRaj Kumar BadamSudheer KanthSugunakar RajuSujan Kumar KothaMadhusudhan RaoK Lalith Prakash ChandraThe embryonic development of salivary glands is a complex process that creates compact, highly organized secretory organs with functions essential for oral health. The development is an example of branching morphogenesis, recent research found to involve unexpectedly dynamic cell motility, and novel regulatory pathways. Numerous growth factors, extracellular matrix molecules, gene regulatory pathways, and mechanical forces contribute to salivary gland morphogenesis, but local gene regulation and morphological changes appear to play particularly notable roles. Salivary gland tumors are one of the most complex and relatively rare groups of lesions encountered in oral pathology practice. Their complexity is attributed to the heterogeneity of the cells of origin of these lesions. Frequent overlap of microscopic features among various neoplasms makes us sometimes even to differentiate benign and malignant lesions leading to a diagnostic dilemma. Here, we review and summarize the current concepts regarding the histogenetic and morphogenetic concepts of salivary gland tumors and their relevance to routine diagnosis and classification of these lesions.http://www.jofs.in/article.asp?issn=0975-8844;year=2015;volume=7;issue=2;spage=76;epage=79;aulast=BadamHistogenetic concepts, morphogenetic concepts, salivary glands |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raj Kumar Badam Sudheer Kanth Sugunakar Raju Sujan Kumar Kotha Madhusudhan Rao K Lalith Prakash Chandra |
spellingShingle |
Raj Kumar Badam Sudheer Kanth Sugunakar Raju Sujan Kumar Kotha Madhusudhan Rao K Lalith Prakash Chandra Current concepts of salivary gland tumors Journal of Orofacial Sciences Histogenetic concepts, morphogenetic concepts, salivary glands |
author_facet |
Raj Kumar Badam Sudheer Kanth Sugunakar Raju Sujan Kumar Kotha Madhusudhan Rao K Lalith Prakash Chandra |
author_sort |
Raj Kumar Badam |
title |
Current concepts of salivary gland tumors |
title_short |
Current concepts of salivary gland tumors |
title_full |
Current concepts of salivary gland tumors |
title_fullStr |
Current concepts of salivary gland tumors |
title_full_unstemmed |
Current concepts of salivary gland tumors |
title_sort |
current concepts of salivary gland tumors |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Orofacial Sciences |
issn |
0975-8844 |
publishDate |
2015-01-01 |
description |
The embryonic development of salivary glands is a complex process that creates compact, highly organized secretory organs with functions essential for oral health. The development is an example of branching morphogenesis, recent research found to involve unexpectedly dynamic cell motility, and novel regulatory pathways. Numerous growth factors, extracellular matrix molecules, gene regulatory pathways, and mechanical forces contribute to salivary gland morphogenesis, but local gene regulation and morphological changes appear to play particularly notable roles. Salivary gland tumors are one of the most complex and relatively rare groups of lesions encountered in oral pathology practice. Their complexity is attributed to the heterogeneity of the cells of origin of these lesions. Frequent overlap of microscopic features among various neoplasms makes us sometimes even to differentiate benign and malignant lesions leading to a diagnostic dilemma. Here, we review and summarize the current concepts regarding the histogenetic and morphogenetic concepts of salivary gland tumors and their relevance to routine diagnosis and classification of these lesions. |
topic |
Histogenetic concepts, morphogenetic concepts, salivary glands |
url |
http://www.jofs.in/article.asp?issn=0975-8844;year=2015;volume=7;issue=2;spage=76;epage=79;aulast=Badam |
work_keys_str_mv |
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