Homeobox Genes and Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, and is the third leading cause of cancer-related deaths each year. It involves a multi-step progression and is strongly associated with chronic inflammation induced by the intake of environmental toxins and/or viral infections (...
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doaj-07e6b5c15b4f4466a856424784563f332020-11-25T00:53:20ZengMDPI AGCancers2072-66942019-05-0111562110.3390/cancers11050621cancers11050621Homeobox Genes and Hepatocellular CarcinomaKwei-Yan Liu0Li-Ting Wang1Shih-Hsien Hsu2Shen-Nien Wang3Graduate Institute of Medicine, College of Medicine, Koahiusng 807, TaiwanGraduate Institute of Medicine, College of Medicine, Koahiusng 807, TaiwanGraduate Institute of Medicine, College of Medicine, Koahiusng 807, TaiwanGraduate Institute of Medicine, College of Medicine, Koahiusng 807, TaiwanHepatocellular carcinoma (HCC) is the sixth most common type of cancer, and is the third leading cause of cancer-related deaths each year. It involves a multi-step progression and is strongly associated with chronic inflammation induced by the intake of environmental toxins and/or viral infections (i.e., hepatitis B and C viruses). Although several genetic dysregulations are considered to be involved in disease progression, the detailed regulatory mechanisms are not well defined. Homeobox genes that encode transcription factors with homeodomains control cell growth, differentiation, and morphogenesis in embryonic development. Recently, more aberrant expressions of Homeobox genes were found in a wide variety of human cancer, including HCC. In this review, we summarize the currently available evidence related to the role of Homeobox genes in the development of HCC. The objective is to determine the roles of this conserved transcription factor family and its potential use as a therapeutic target in future investigations.https://www.mdpi.com/2072-6694/11/5/621HomeoboxHCCEMTimmunosuppressionIL6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kwei-Yan Liu Li-Ting Wang Shih-Hsien Hsu Shen-Nien Wang |
spellingShingle |
Kwei-Yan Liu Li-Ting Wang Shih-Hsien Hsu Shen-Nien Wang Homeobox Genes and Hepatocellular Carcinoma Cancers Homeobox HCC EMT immunosuppression IL6 |
author_facet |
Kwei-Yan Liu Li-Ting Wang Shih-Hsien Hsu Shen-Nien Wang |
author_sort |
Kwei-Yan Liu |
title |
Homeobox Genes and Hepatocellular Carcinoma |
title_short |
Homeobox Genes and Hepatocellular Carcinoma |
title_full |
Homeobox Genes and Hepatocellular Carcinoma |
title_fullStr |
Homeobox Genes and Hepatocellular Carcinoma |
title_full_unstemmed |
Homeobox Genes and Hepatocellular Carcinoma |
title_sort |
homeobox genes and hepatocellular carcinoma |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2019-05-01 |
description |
Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, and is the third leading cause of cancer-related deaths each year. It involves a multi-step progression and is strongly associated with chronic inflammation induced by the intake of environmental toxins and/or viral infections (i.e., hepatitis B and C viruses). Although several genetic dysregulations are considered to be involved in disease progression, the detailed regulatory mechanisms are not well defined. Homeobox genes that encode transcription factors with homeodomains control cell growth, differentiation, and morphogenesis in embryonic development. Recently, more aberrant expressions of Homeobox genes were found in a wide variety of human cancer, including HCC. In this review, we summarize the currently available evidence related to the role of Homeobox genes in the development of HCC. The objective is to determine the roles of this conserved transcription factor family and its potential use as a therapeutic target in future investigations. |
topic |
Homeobox HCC EMT immunosuppression IL6 |
url |
https://www.mdpi.com/2072-6694/11/5/621 |
work_keys_str_mv |
AT kweiyanliu homeoboxgenesandhepatocellularcarcinoma AT litingwang homeoboxgenesandhepatocellularcarcinoma AT shihhsienhsu homeoboxgenesandhepatocellularcarcinoma AT shennienwang homeoboxgenesandhepatocellularcarcinoma |
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1725237957898534912 |