Impact of age and gender on the clinicopathological characteristics of bladder cancer
Purpose: To determine the impact of age and gender on the clinicopathological characteristics of histologically confirmed bladder cancer in India. Materials and Methods: From January 2001 to June 2008, records of patients with bladder cancer were evaluated for age and gender at presentation, clinic...
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doaj-07ebf233a1fc4876bea69e9f8aa893072020-11-24T22:48:14ZengWolters Kluwer Medknow PublicationsIndian Journal of Urology0970-15911998-38242009-01-0125220721010.4103/0970-1591.52916Impact of age and gender on the clinicopathological characteristics of bladder cancerParag GuptaManoj JainRakesh KapoorK MuruganandhamAneesh SrivastavaAnil MandhaniPurpose: To determine the impact of age and gender on the clinicopathological characteristics of histologically confirmed bladder cancer in India. Materials and Methods: From January 2001 to June 2008, records of patients with bladder cancer were evaluated for age and gender at presentation, clinical symptoms, cystoscopic finding, history of smoking, and histopathological characteristics. A total of 561 patients were identified from the computer-based hospital information system and the case files of patients. Results: A total of 97% of the patients presented with painless hematuria. The mean age was 60.2 ± 4.4 years old (range: 18-90 years old) and the male to female ratio was 8.6:1. Transitional cell carcinoma (TCC) was the most common histological variety, which was present in 97.71% (470 of 481) of the patients. A total of 26% of the patients had muscle invasive disease at the time of presentation. However, 34.5% (166 of 481) of the patients did not show any evidence of detrusor muscle in their biopsy specimen. In patients with nonmuscle-invasive bladder carcinoma, 55% had p Ta while 45% had p T1. Overall, 44.7% (215 of 481) of the patients had low-grade disease. Among patients younger than 60 years old, low-grade (51.0% vs. 38.1%; P = 0.006) and low-stage (77.1% vs. 70.8%; P = 0.119) disease were more prevalent than in patients older than 60 years old. The incidence of smoking was much higher among males compared with females (74% vs. 22%). Conclusion: TCC is the predominant cancer, with significant male preponderance among Indian patients. Younger-aged patients have low-grade disease. Hematuria is the most common presentation and greater awareness is needed not to overlook bladder cancer.http://www.indianjurol.com/article.asp?issn=0970-1591;year=2009;volume=25;issue=2;spage=207;epage=210;aulast=GuptaAgebladder cancergendersmokingtransitional cell carcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Parag Gupta Manoj Jain Rakesh Kapoor K Muruganandham Aneesh Srivastava Anil Mandhani |
spellingShingle |
Parag Gupta Manoj Jain Rakesh Kapoor K Muruganandham Aneesh Srivastava Anil Mandhani Impact of age and gender on the clinicopathological characteristics of bladder cancer Indian Journal of Urology Age bladder cancer gender smoking transitional cell carcinoma |
author_facet |
Parag Gupta Manoj Jain Rakesh Kapoor K Muruganandham Aneesh Srivastava Anil Mandhani |
author_sort |
Parag Gupta |
title |
Impact of age and gender on the clinicopathological characteristics of bladder cancer |
title_short |
Impact of age and gender on the clinicopathological characteristics of bladder cancer |
title_full |
Impact of age and gender on the clinicopathological characteristics of bladder cancer |
title_fullStr |
Impact of age and gender on the clinicopathological characteristics of bladder cancer |
title_full_unstemmed |
Impact of age and gender on the clinicopathological characteristics of bladder cancer |
title_sort |
impact of age and gender on the clinicopathological characteristics of bladder cancer |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Urology |
issn |
0970-1591 1998-3824 |
publishDate |
2009-01-01 |
description |
Purpose: To determine the impact of age and gender on the clinicopathological characteristics of histologically confirmed bladder cancer in India.
Materials and Methods: From January 2001 to June 2008, records of patients with bladder cancer were evaluated for age and gender at presentation, clinical symptoms, cystoscopic finding, history of smoking, and histopathological characteristics. A total of 561 patients were identified from the computer-based hospital information system and the case files of patients.
Results: A total of 97% of the patients presented with painless hematuria. The mean age was 60.2 ± 4.4 years old (range: 18-90 years old) and the male to female ratio was 8.6:1. Transitional cell carcinoma (TCC) was the most common histological variety, which was present in 97.71% (470 of 481) of the patients. A total of 26% of the patients had muscle invasive disease at the time of presentation. However, 34.5% (166 of 481) of the patients did not show any evidence of detrusor muscle in their biopsy specimen. In patients with nonmuscle-invasive bladder carcinoma, 55% had p Ta while 45% had p T1. Overall, 44.7% (215 of 481) of the patients had low-grade disease. Among patients younger than 60 years old, low-grade (51.0% vs. 38.1%; P = 0.006) and low-stage (77.1% vs. 70.8%; P = 0.119) disease were more prevalent than in patients older than 60 years old. The incidence of smoking was much higher among males compared with females (74% vs. 22%).
Conclusion: TCC is the predominant cancer, with significant male preponderance among Indian patients. Younger-aged patients have low-grade disease. Hematuria is the most common presentation and greater awareness is needed not to overlook bladder cancer. |
topic |
Age bladder cancer gender smoking transitional cell carcinoma |
url |
http://www.indianjurol.com/article.asp?issn=0970-1591;year=2009;volume=25;issue=2;spage=207;epage=210;aulast=Gupta |
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AT paraggupta impactofageandgenderontheclinicopathologicalcharacteristicsofbladdercancer AT manojjain impactofageandgenderontheclinicopathologicalcharacteristicsofbladdercancer AT rakeshkapoor impactofageandgenderontheclinicopathologicalcharacteristicsofbladdercancer AT kmuruganandham impactofageandgenderontheclinicopathologicalcharacteristicsofbladdercancer AT aneeshsrivastava impactofageandgenderontheclinicopathologicalcharacteristicsofbladdercancer AT anilmandhani impactofageandgenderontheclinicopathologicalcharacteristicsofbladdercancer |
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