Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal Failure
For the pediatric nephrologist, the over-the-counter status for non-steroidal anti-inflammatory drugs (NSAIDs) is surprising due to their possible harmful side effects. These can include acute renal failure due mainly to glomerular hypoperfusion which may lead to acute tubular necrosis; more rarely...
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doaj-07f292b845ff463c9dda5872155afb1b2020-11-24T21:40:55ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-01-01710.3389/fped.2019.00517439385Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal FailureAlbert BensmanFor the pediatric nephrologist, the over-the-counter status for non-steroidal anti-inflammatory drugs (NSAIDs) is surprising due to their possible harmful side effects. These can include acute renal failure due mainly to glomerular hypoperfusion which may lead to acute tubular necrosis; more rarely in children, medullary ischemic injury and cardiovascular diseases; acute or chronic interstitial nephritis which may cause chronic renal failure. All of them may create electrolyte abnormalities: hyponatremia, hyperkaliemia, renal tubular acidosis, fluid retention causing hypertension.https://www.frontiersin.org/article/10.3389/fped.2019.00517/fullnon-steroidal anti-infammatory drugsvolume depletionacute renal failurearachidonic acidprostaglandin E2interstitial nephritis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Albert Bensman |
spellingShingle |
Albert Bensman Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal Failure Frontiers in Pediatrics non-steroidal anti-infammatory drugs volume depletion acute renal failure arachidonic acid prostaglandin E2 interstitial nephritis |
author_facet |
Albert Bensman |
author_sort |
Albert Bensman |
title |
Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal Failure |
title_short |
Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal Failure |
title_full |
Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal Failure |
title_fullStr |
Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal Failure |
title_full_unstemmed |
Non-steroidal Anti-inflammatory Drugs (NSAIDs) Systemic Use: The Risk of Renal Failure |
title_sort |
non-steroidal anti-inflammatory drugs (nsaids) systemic use: the risk of renal failure |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2020-01-01 |
description |
For the pediatric nephrologist, the over-the-counter status for non-steroidal anti-inflammatory drugs (NSAIDs) is surprising due to their possible harmful side effects. These can include acute renal failure due mainly to glomerular hypoperfusion which may lead to acute tubular necrosis; more rarely in children, medullary ischemic injury and cardiovascular diseases; acute or chronic interstitial nephritis which may cause chronic renal failure. All of them may create electrolyte abnormalities: hyponatremia, hyperkaliemia, renal tubular acidosis, fluid retention causing hypertension. |
topic |
non-steroidal anti-infammatory drugs volume depletion acute renal failure arachidonic acid prostaglandin E2 interstitial nephritis |
url |
https://www.frontiersin.org/article/10.3389/fped.2019.00517/full |
work_keys_str_mv |
AT albertbensman nonsteroidalantiinflammatorydrugsnsaidssystemicusetheriskofrenalfailure |
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