The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery

The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery

DNA replication is an essential process. Although the fundamental strategies to duplicate chromosomes are similar in all free-living organisms, the enzymes of the three domains of life that perform similar functions in DNA replication differ in amino acid sequence and their three-dimensional structu...

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Bibliographic Details
Main Author: Jon M. Kaguni
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Antibiotics
Subjects:
DNA replication
Escherichia coli
inhibitors
replisome
replication fork
initiation
replication origin
DnaA
DnaB
DnaC
primase
DnaG
SSB
DNA gyrase
topoisomerase IV
DNA polymerase I
DNA polymerase III holoenzyme
sliding clamp
clamp loader
DNA ligase
Online Access:http://www.mdpi.com/2079-6382/7/1/23

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http://www.mdpi.com/2079-6382/7/1/23

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