Crosstalk Between DNA Methylation and Gene Mutations in Colorectal Cancer

Crosstalk Between DNA Methylation and Gene Mutations in Colorectal Cancer

Colorectal cancer (CRC) is often characterized by mutations and aberrant DNA methylation within the promoters of tumor suppressor genes and proto-oncogenes. The most frequent somatic mutations occur within KRAS and BRAF genes. Mutations of the KRAS gene have been detected in approximately 40% of pat...

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Bibliographic Details
Main Authors: Maria Dobre, Alessandro Salvi, Iulia Andreea Pelisenco, Florina Vasilescu, Giuseppina De Petro, Vlad Herlea, Elena Milanesi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
DNA methylation
KRAS
BRAF
mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.697409/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.697409/full

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