WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes

WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes

After autophagic cargo degradation, autolysosomes undergo a reformation process to recycle lysosomal membrane components. Here, Dai et al. demonstrate that the actin nucleation promoting factor WHAMM is required for autolysosome reformation by providing an actin scaffold to drive tubulation.

Bibliographic Details
Main Authors: Anbang Dai, Li Yu, Hong-Wei Wang
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11694-9
id doaj-081945393053411d8f5e25f9f81b3e8d
record_format Article
spelling doaj-081945393053411d8f5e25f9f81b3e8d2021-05-11T12:35:15ZengNature Publishing GroupNature Communications2041-17232019-08-0110111410.1038/s41467-019-11694-9WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomesAnbang Dai0Li Yu1Hong-Wei Wang2Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking University Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Science, Tsinghua UniversityState Key Laboratory of Membrane Biology, Tsinghua-Peking University Joint Center for Life Sciences, School of Life Science, Tsinghua UniversityMinistry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking University Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Science, Tsinghua UniversityAfter autophagic cargo degradation, autolysosomes undergo a reformation process to recycle lysosomal membrane components. Here, Dai et al. demonstrate that the actin nucleation promoting factor WHAMM is required for autolysosome reformation by providing an actin scaffold to drive tubulation.https://doi.org/10.1038/s41467-019-11694-9
collection DOAJ
language English
format Article
sources DOAJ
author Anbang Dai
Li Yu
Hong-Wei Wang
spellingShingle Anbang Dai
Li Yu
Hong-Wei Wang
WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
Nature Communications
author_facet Anbang Dai
Li Yu
Hong-Wei Wang
author_sort Anbang Dai
title WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
title_short WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
title_full WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
title_fullStr WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
title_full_unstemmed WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
title_sort whamm initiates autolysosome tubulation by promoting actin polymerization on autolysosomes
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-08-01
description After autophagic cargo degradation, autolysosomes undergo a reformation process to recycle lysosomal membrane components. Here, Dai et al. demonstrate that the actin nucleation promoting factor WHAMM is required for autolysosome reformation by providing an actin scaffold to drive tubulation.
url https://doi.org/10.1038/s41467-019-11694-9
work_keys_str_mv AT anbangdai whamminitiatesautolysosometubulationbypromotingactinpolymerizationonautolysosomes
AT liyu whamminitiatesautolysosometubulationbypromotingactinpolymerizationonautolysosomes
AT hongweiwang whamminitiatesautolysosometubulationbypromotingactinpolymerizationonautolysosomes
_version_ 1721444545281916928

Similar Items