Growth charts for Thai children with Prader-Willi syndrome aged 0–18 years
Abstract Background Prader-Willi syndrome (PWS) is a multisystem genetic disorder, which has a typical eating behavior and growth pattern. In the infancy period, children with PWS have low body weight followed by hyperphagia in later childhood. Disease-specific growth charts have been recommended fo...
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doaj-0822a97fde054ffd9275efae1ec55e1c2020-11-25T02:18:33ZengBMCOrphanet Journal of Rare Diseases1750-11722020-05-011511910.1186/s13023-020-01388-7Growth charts for Thai children with Prader-Willi syndrome aged 0–18 yearsNantiya Mongkollarp0Thipwimol Tim-Aroon1Chusak Okascharoen2Khunton Wichajarn3Jeeraparn Phosuwattanakul4Nalinee Chongviriyaphan5Duangrurdee Wattanasirichaigoon6Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDivision of Medical Genetics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDivision of Evidence-based Pediatrics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDivision of Medical Genetics, Department of Pediatrics, Faculty of Medicine, Khon Kaen UniversityDivision of Nutrition, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDivision of Nutrition, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityDivision of Medical Genetics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityAbstract Background Prader-Willi syndrome (PWS) is a multisystem genetic disorder, which has a typical eating behavior and growth pattern. In the infancy period, children with PWS have low body weight followed by hyperphagia in later childhood. Disease-specific growth charts have been recommended for monitoring PWS patients. Previous literature demonstrated growth differences among individuals with PWS of different ethnicity. Methods A retrospective multicenter study was performed in PWS patients from different areas of Thailand included collaboration with the Thai PWS support group during 2000–2017. Baseline characteristics and anthropometric data were reviewed. Both growth hormone and non-growth hormone received patients were included, but the data after receiving GH were excluded before curve construction. Growth charts for Thai PWS compared to the 50th normative centile were constructed using Generalized Least Squares (GLS) methods. Curve smoothing was performed by Fractional Polynomials and Exponential Transformation. Result One hundred and thirteen patients with genetically confirmed PWS (55 males and 58 females) were enrolled. Fifty percent of patients were diagnosed less than 6 months of age. We developed growth charts for non-growth hormone treated Thai children with PWS aged between 0 and 18 years. A growth pattern was similar to other ethnicities while there were some differences. Mean birth weight of PWS patients was less than that of typical newborns. Mean adult height at 18 years of age in Thai children with PWS was lower than that in American children, but taller than Japanese. Mean weight of Thai PWS males at 18 years of age was more than those from other countries. Conclusion This study is the first to document PWS-specific growth charts in Southeast Asian population. These growth charts will be useful in improving the quality of patient care and in evaluating the impact of growth hormone treatment in the future.http://link.springer.com/article/10.1186/s13023-020-01388-7Prader-Willi syndromeGrowth chartBody heightBody weightHead circumferenceSoutheast Asian |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nantiya Mongkollarp Thipwimol Tim-Aroon Chusak Okascharoen Khunton Wichajarn Jeeraparn Phosuwattanakul Nalinee Chongviriyaphan Duangrurdee Wattanasirichaigoon |
spellingShingle |
Nantiya Mongkollarp Thipwimol Tim-Aroon Chusak Okascharoen Khunton Wichajarn Jeeraparn Phosuwattanakul Nalinee Chongviriyaphan Duangrurdee Wattanasirichaigoon Growth charts for Thai children with Prader-Willi syndrome aged 0–18 years Orphanet Journal of Rare Diseases Prader-Willi syndrome Growth chart Body height Body weight Head circumference Southeast Asian |
author_facet |
Nantiya Mongkollarp Thipwimol Tim-Aroon Chusak Okascharoen Khunton Wichajarn Jeeraparn Phosuwattanakul Nalinee Chongviriyaphan Duangrurdee Wattanasirichaigoon |
author_sort |
Nantiya Mongkollarp |
title |
Growth charts for Thai children with Prader-Willi syndrome aged 0–18 years |
title_short |
Growth charts for Thai children with Prader-Willi syndrome aged 0–18 years |
title_full |
Growth charts for Thai children with Prader-Willi syndrome aged 0–18 years |
title_fullStr |
Growth charts for Thai children with Prader-Willi syndrome aged 0–18 years |
title_full_unstemmed |
Growth charts for Thai children with Prader-Willi syndrome aged 0–18 years |
title_sort |
growth charts for thai children with prader-willi syndrome aged 0–18 years |
publisher |
BMC |
series |
Orphanet Journal of Rare Diseases |
issn |
1750-1172 |
publishDate |
2020-05-01 |
description |
Abstract Background Prader-Willi syndrome (PWS) is a multisystem genetic disorder, which has a typical eating behavior and growth pattern. In the infancy period, children with PWS have low body weight followed by hyperphagia in later childhood. Disease-specific growth charts have been recommended for monitoring PWS patients. Previous literature demonstrated growth differences among individuals with PWS of different ethnicity. Methods A retrospective multicenter study was performed in PWS patients from different areas of Thailand included collaboration with the Thai PWS support group during 2000–2017. Baseline characteristics and anthropometric data were reviewed. Both growth hormone and non-growth hormone received patients were included, but the data after receiving GH were excluded before curve construction. Growth charts for Thai PWS compared to the 50th normative centile were constructed using Generalized Least Squares (GLS) methods. Curve smoothing was performed by Fractional Polynomials and Exponential Transformation. Result One hundred and thirteen patients with genetically confirmed PWS (55 males and 58 females) were enrolled. Fifty percent of patients were diagnosed less than 6 months of age. We developed growth charts for non-growth hormone treated Thai children with PWS aged between 0 and 18 years. A growth pattern was similar to other ethnicities while there were some differences. Mean birth weight of PWS patients was less than that of typical newborns. Mean adult height at 18 years of age in Thai children with PWS was lower than that in American children, but taller than Japanese. Mean weight of Thai PWS males at 18 years of age was more than those from other countries. Conclusion This study is the first to document PWS-specific growth charts in Southeast Asian population. These growth charts will be useful in improving the quality of patient care and in evaluating the impact of growth hormone treatment in the future. |
topic |
Prader-Willi syndrome Growth chart Body height Body weight Head circumference Southeast Asian |
url |
http://link.springer.com/article/10.1186/s13023-020-01388-7 |
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