Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis
Introduction: Fibrinogen degradation products (FDPs) are the products that are released from fibrin/fibrinogen. Recently, it has been observed that these FDPs have been identified in the plasma of OSMF patients. Areca nut being the major aetiological agent for OSMF may play a role in the increas...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2014-11-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/5123/9854_CE(Ra)_F(Sh)_PF1(AJAK)_PFA(Sh)_PFA2(AK)_PF2(PAG).pdf |
Summary: | Introduction: Fibrinogen degradation products (FDPs) are the
products that are released from fibrin/fibrinogen. Recently, it
has been observed that these FDPs have been identified in the
plasma of OSMF patients. Areca nut being the major aetiological
agent for OSMF may play a role in the increased plasma levels
of FDPs in OSMF.
Aim: The aim of this study was to quantify the plasma FDPs
levels in the individuals with the habit of areca nut chewing with
and without OSMF.
Materials & Methods: Total of 95 subjects were included,35
subjects with the habit of areca nut chewing with OSMF, 30
with the habit of areca nut chewing without OSMF, 30 without
any habit of areca nut chewing without OSMF (control group).
Five ml of venous blood was withdrawn from all the subjects
and plasma FDP levels were estimated.
Results: Plasma FDPs were detected in all the subjects of
OSMF but could not be detected in other two groups. As the
clinical grades of OSMF increased, levels of plasma FDPs also
increased.
Conclusion: When plasma FDP increases, fibrin deposition
also increases. This strengthens the finding that these FDPs
may be an early indicator of the OSMF. |
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ISSN: | 2249-782X 0973-709X |