The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications

The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications

The analysis of microRNA (miRNAs), small, non-coding endogenous RNA, plays a crucial role in oncology. These short regulatory sequences, acting on thousands of messenger RNAs (mRNAs), modulate gene expression at the transcriptional and post-transcriptional level leading to translational repression o...

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Main Authors: Federica Spadaccino, Margherita Gigante, Giuseppe Stefano Netti, Maria Teresa Rocchetti, Rossana Franzin, Loreto Gesualdo, Giuseppe Castellano, Giovanni Stallone, Elena Ranieri
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
miRNAs
cancer
renal cell carcinoma
biomarkers
Online Access:https://www.mdpi.com/1424-8247/14/4/322
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spelling doaj-082ecc18189b4d2aa05cdff0bb9931f12021-04-02T23:00:57ZengMDPI AGPharmaceuticals1424-82472021-04-011432232210.3390/ph14040322The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical ApplicationsFederica Spadaccino0Margherita Gigante1Giuseppe Stefano Netti2Maria Teresa Rocchetti3Rossana Franzin4Loreto Gesualdo5Giuseppe Castellano6Giovanni Stallone7Elena Ranieri8Clinical Pathology Unit, Center of Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyClinical Pathology Unit, Center of Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyClinical Pathology Unit, Center of Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyNephrology Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyNephrology Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyClinical Pathology Unit, Center of Molecular Medicine, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, ItalyThe analysis of microRNA (miRNAs), small, non-coding endogenous RNA, plays a crucial role in oncology. These short regulatory sequences, acting on thousands of messenger RNAs (mRNAs), modulate gene expression at the transcriptional and post-transcriptional level leading to translational repression or degradation of target molecules. Although their function is required for several physiological processes, such as proliferation, apoptosis and cell differentiation, miRNAs are also responsible for development and/or progression of several cancers, since they may interact with classical tumor pathways. In this review, we highlight recent advances in deregulated miRNAs in cancer focusing on renal cell carcinoma (RCC) and provide an overview of the potential use of miRNA in their clinical settings, such as diagnostic and prognostic markers.https://www.mdpi.com/1424-8247/14/4/322miRNAscancerrenal cell carcinomabiomarkers
collection DOAJ
language English
format Article
sources DOAJ
author Federica Spadaccino
Margherita Gigante
Giuseppe Stefano Netti
Maria Teresa Rocchetti
Rossana Franzin
Loreto Gesualdo
Giuseppe Castellano
Giovanni Stallone
Elena Ranieri
spellingShingle Federica Spadaccino
Margherita Gigante
Giuseppe Stefano Netti
Maria Teresa Rocchetti
Rossana Franzin
Loreto Gesualdo
Giuseppe Castellano
Giovanni Stallone
Elena Ranieri
The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications
Pharmaceuticals
miRNAs
cancer
renal cell carcinoma
biomarkers
author_facet Federica Spadaccino
Margherita Gigante
Giuseppe Stefano Netti
Maria Teresa Rocchetti
Rossana Franzin
Loreto Gesualdo
Giuseppe Castellano
Giovanni Stallone
Elena Ranieri
author_sort Federica Spadaccino
title The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications
title_short The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications
title_full The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications
title_fullStr The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications
title_full_unstemmed The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications
title_sort ambivalent role of mirnas in carcinogenesis: involvement in renal cell carcinoma and their clinical applications
publisher MDPI AG
series Pharmaceuticals
issn 1424-8247
publishDate 2021-04-01
description The analysis of microRNA (miRNAs), small, non-coding endogenous RNA, plays a crucial role in oncology. These short regulatory sequences, acting on thousands of messenger RNAs (mRNAs), modulate gene expression at the transcriptional and post-transcriptional level leading to translational repression or degradation of target molecules. Although their function is required for several physiological processes, such as proliferation, apoptosis and cell differentiation, miRNAs are also responsible for development and/or progression of several cancers, since they may interact with classical tumor pathways. In this review, we highlight recent advances in deregulated miRNAs in cancer focusing on renal cell carcinoma (RCC) and provide an overview of the potential use of miRNA in their clinical settings, such as diagnostic and prognostic markers.
topic miRNAs
cancer
renal cell carcinoma
biomarkers
url https://www.mdpi.com/1424-8247/14/4/322
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