Case Presentation of a 23-Month-old Herpes Simplex Virus-infected Girl with Brain and Oesophageal Involvement
Herpes simplex virus (HSV) is the most common identifiable cause of serious or life threatening sporadic, endemic encephalitis. Typical HSV encephalitis in patients outside neonatal age is caused by HSV-1. A 23-month-old girl was referred to our hospital with a three-day history of fever, listless...
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doaj-0831eebbdfa44a37bdda94948fdf1b532020-11-25T03:52:38ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-05-0195SD03SD0410.7860/JCDR/2015/12485.5979Case Presentation of a 23-Month-old Herpes Simplex Virus-infected Girl with Brain and Oesophageal InvolvementKaram-Ali Kasiri0Noushin Rostampour1Abolfazl Khoshdel2Assistant Professor, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.Assistant Professor, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.Associate Professor, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.Herpes simplex virus (HSV) is the most common identifiable cause of serious or life threatening sporadic, endemic encephalitis. Typical HSV encephalitis in patients outside neonatal age is caused by HSV-1. A 23-month-old girl was referred to our hospital with a three-day history of fever, listlessness, slurred speech, and suspicious oesophageal foreign body impaction. Laboratory evaluations showed white blood cell count of 10900 /mm3 with 65% neutrophils. Upper endoscopy revealed diffuse severe ulceration in middle to distal third of oesophagus and no foreign body was found in oesophagus or stomach. Parenteral acyclovir was prescribed for herpes encephalitis in addition to antibiotics for central nervous system infection. Chest X-ray and brain MRI was unremarkable. Lumbar puncture revealed normal protein and glucose with 10 white cell count. She developed a raising liver enzyme tests. Total and direct bilirubin was 1.2 mg/dc and 0.2 mg/dc respectively. Because of neurological symptoms, acyclovir was adopted for our patient from the beginning. The girl did not respond to medication and died after 28 days. Progression of her disease prior to referral appears to contribute to the administered treatment inefficacy. Severe rapid progression of disease prior to referral and potential resistance to acyclovir could cause treatment failure.https://jcdr.net/articles/PDF/5979/12485_CE(RA1)_F(T)_PF1(AGAK)_PFA(AK)_PF2(AGAK).pdfacyclovirencephalopathyherpes simplex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karam-Ali Kasiri Noushin Rostampour Abolfazl Khoshdel |
spellingShingle |
Karam-Ali Kasiri Noushin Rostampour Abolfazl Khoshdel Case Presentation of a 23-Month-old Herpes Simplex Virus-infected Girl with Brain and Oesophageal Involvement Journal of Clinical and Diagnostic Research acyclovir encephalopathy herpes simplex |
author_facet |
Karam-Ali Kasiri Noushin Rostampour Abolfazl Khoshdel |
author_sort |
Karam-Ali Kasiri |
title |
Case Presentation of a 23-Month-old Herpes Simplex Virus-infected Girl with Brain and Oesophageal Involvement |
title_short |
Case Presentation of a 23-Month-old Herpes Simplex Virus-infected Girl with Brain and Oesophageal Involvement |
title_full |
Case Presentation of a 23-Month-old Herpes Simplex Virus-infected Girl with Brain and Oesophageal Involvement |
title_fullStr |
Case Presentation of a 23-Month-old Herpes Simplex Virus-infected Girl with Brain and Oesophageal Involvement |
title_full_unstemmed |
Case Presentation of a 23-Month-old Herpes Simplex Virus-infected Girl with Brain and Oesophageal Involvement |
title_sort |
case presentation of a 23-month-old herpes simplex virus-infected girl with brain and oesophageal involvement |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2015-05-01 |
description |
Herpes simplex virus (HSV) is the most common identifiable cause of serious or life threatening sporadic, endemic encephalitis. Typical HSV
encephalitis in patients outside neonatal age is caused by HSV-1. A 23-month-old girl was referred to our hospital with a three-day history
of fever, listlessness, slurred speech, and suspicious oesophageal foreign body impaction. Laboratory evaluations showed white blood cell
count of 10900 /mm3
with 65% neutrophils. Upper endoscopy revealed diffuse severe ulceration in middle to distal third of oesophagus and
no foreign body was found in oesophagus or stomach. Parenteral acyclovir was prescribed for herpes encephalitis in addition to antibiotics
for central nervous system infection. Chest X-ray and brain MRI was unremarkable. Lumbar puncture revealed normal protein and glucose
with 10 white cell count. She developed a raising liver enzyme tests. Total and direct bilirubin was 1.2 mg/dc and 0.2 mg/dc respectively.
Because of neurological symptoms, acyclovir was adopted for our patient from the beginning. The girl did not respond to medication and
died after 28 days. Progression of her disease prior to referral appears to contribute to the administered treatment inefficacy. Severe rapid
progression of disease prior to referral and potential resistance to acyclovir could cause treatment failure. |
topic |
acyclovir encephalopathy herpes simplex |
url |
https://jcdr.net/articles/PDF/5979/12485_CE(RA1)_F(T)_PF1(AGAK)_PFA(AK)_PF2(AGAK).pdf |
work_keys_str_mv |
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