Effect of sodium benzoate on DNA breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newborns
Sodium benzoate (SB) is one of the most widely used additives in food products in the world. The aim of this study was to assess the effect of three different concentrations of SB on the DNA breakage in liver cells and on the micronuclei formation and the mitotic index in lymphocytes of pregnant rat...
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2016-11-01
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Online Access: | http://dx.doi.org/10.1080/13102818.2016.1224979 |
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doaj-0834ad4bd14f42adb924a09b02e8641a2020-11-25T00:13:24ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302016-11-013061179118310.1080/13102818.2016.12249791224979Effect of sodium benzoate on DNA breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newbornsCetin Saatci0Yagut Erdem1Ruslan Bayramov2Hilal Akalın3Nazife Tascioglu4Yusuf Ozkul5Erciyes UniversityErciyes UniversityErciyes UniversityErciyes UniversityErciyes UniversityErciyes UniversitySodium benzoate (SB) is one of the most widely used additives in food products in the world. The aim of this study was to assess the effect of three different concentrations of SB on the DNA breakage in liver cells and on the micronuclei formation and the mitotic index in lymphocytes of pregnant rats and their fetuses, as well as to evaluate the effects of SB on the fetus development. The results showed that general genomic injuries were present in almost all the liver cell samples obtained from the SB group compared with the control (non-treated) group. This indicates that SB usage may cause DNA damage and increase micronuclei formation. We recommend that pregnant women should avoid consuming foodstuffs containing SB as an additive.http://dx.doi.org/10.1080/13102818.2016.1224979DNA damagesodium benzoatemicronucleusfood additives |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cetin Saatci Yagut Erdem Ruslan Bayramov Hilal Akalın Nazife Tascioglu Yusuf Ozkul |
spellingShingle |
Cetin Saatci Yagut Erdem Ruslan Bayramov Hilal Akalın Nazife Tascioglu Yusuf Ozkul Effect of sodium benzoate on DNA breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newborns Biotechnology & Biotechnological Equipment DNA damage sodium benzoate micronucleus food additives |
author_facet |
Cetin Saatci Yagut Erdem Ruslan Bayramov Hilal Akalın Nazife Tascioglu Yusuf Ozkul |
author_sort |
Cetin Saatci |
title |
Effect of sodium benzoate on DNA breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newborns |
title_short |
Effect of sodium benzoate on DNA breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newborns |
title_full |
Effect of sodium benzoate on DNA breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newborns |
title_fullStr |
Effect of sodium benzoate on DNA breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newborns |
title_full_unstemmed |
Effect of sodium benzoate on DNA breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newborns |
title_sort |
effect of sodium benzoate on dna breakage, micronucleus formation and mitotic index in peripheral blood of pregnant rats and their newborns |
publisher |
Taylor & Francis Group |
series |
Biotechnology & Biotechnological Equipment |
issn |
1310-2818 1314-3530 |
publishDate |
2016-11-01 |
description |
Sodium benzoate (SB) is one of the most widely used additives in food products in the world. The aim of this study was to assess the effect of three different concentrations of SB on the DNA breakage in liver cells and on the micronuclei formation and the mitotic index in lymphocytes of pregnant rats and their fetuses, as well as to evaluate the effects of SB on the fetus development. The results showed that general genomic injuries were present in almost all the liver cell samples obtained from the SB group compared with the control (non-treated) group. This indicates that SB usage may cause DNA damage and increase micronuclei formation. We recommend that pregnant women should avoid consuming foodstuffs containing SB as an additive. |
topic |
DNA damage sodium benzoate micronucleus food additives |
url |
http://dx.doi.org/10.1080/13102818.2016.1224979 |
work_keys_str_mv |
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