A direct and non-invasive method for kidney delivery of therapeutics in mice

A direct and non-invasive method for kidney delivery of therapeutics in mice

Kidney is a vital organ that maintains the homeostasis in terms of acid-balance, toxin filtration and blood pressure control. Kidney malfunction can be fatal and the renal research administers testing pharmaceutical agents or stem cells in rodents to study their therapeutic efficacy. However, target...

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Main Authors: Nimshitha Pavathuparambil Abdul Manaph, Mohammed Al-Hawwas, Xin-Fu Zhou
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:MethodsX
Online Access:http://www.sciencedirect.com/science/article/pii/S2215016118301766
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spelling doaj-0841e6a0b039493bbb07de7f855f36212020-11-25T01:48:46ZengElsevierMethodsX2215-01612018-01-01514401446A direct and non-invasive method for kidney delivery of therapeutics in miceNimshitha Pavathuparambil Abdul Manaph0Mohammed Al-Hawwas1Xin-Fu Zhou2School of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, 5000, Australia; Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, 5000, Australia; School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, 5000, Australia; Corresponding author at: School of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, 5000, Australia.School of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, 5000, AustraliaSchool of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, 5000, AustraliaKidney is a vital organ that maintains the homeostasis in terms of acid-balance, toxin filtration and blood pressure control. Kidney malfunction can be fatal and the renal research administers testing pharmaceutical agents or stem cells in rodents to study their therapeutic efficacy. However, targeted delivery of agents into mice kidney is strenuous and may require laparotomy. Here we present a direct delivery method for cell transplantation or drug injection into the mice kidney. The method is simple and can be performed non-invasively with avoidance of surgical intervention on the animals. Nevertheless, this method serves as an efficient method for in vivo drug delivery or engraftment studies for renal research. • Direct delivery into the kidney. • Non-invasive method. Method name: Direction injection into mice kidney, Keywords: Kidney, Drugs, Delivery, Surgery, Injectionhttp://www.sciencedirect.com/science/article/pii/S2215016118301766
collection DOAJ
language English
format Article
sources DOAJ
author Nimshitha Pavathuparambil Abdul Manaph
Mohammed Al-Hawwas
Xin-Fu Zhou
spellingShingle Nimshitha Pavathuparambil Abdul Manaph
Mohammed Al-Hawwas
Xin-Fu Zhou
A direct and non-invasive method for kidney delivery of therapeutics in mice
MethodsX
author_facet Nimshitha Pavathuparambil Abdul Manaph
Mohammed Al-Hawwas
Xin-Fu Zhou
author_sort Nimshitha Pavathuparambil Abdul Manaph
title A direct and non-invasive method for kidney delivery of therapeutics in mice
title_short A direct and non-invasive method for kidney delivery of therapeutics in mice
title_full A direct and non-invasive method for kidney delivery of therapeutics in mice
title_fullStr A direct and non-invasive method for kidney delivery of therapeutics in mice
title_full_unstemmed A direct and non-invasive method for kidney delivery of therapeutics in mice
title_sort direct and non-invasive method for kidney delivery of therapeutics in mice
publisher Elsevier
series MethodsX
issn 2215-0161
publishDate 2018-01-01
description Kidney is a vital organ that maintains the homeostasis in terms of acid-balance, toxin filtration and blood pressure control. Kidney malfunction can be fatal and the renal research administers testing pharmaceutical agents or stem cells in rodents to study their therapeutic efficacy. However, targeted delivery of agents into mice kidney is strenuous and may require laparotomy. Here we present a direct delivery method for cell transplantation or drug injection into the mice kidney. The method is simple and can be performed non-invasively with avoidance of surgical intervention on the animals. Nevertheless, this method serves as an efficient method for in vivo drug delivery or engraftment studies for renal research. • Direct delivery into the kidney. • Non-invasive method. Method name: Direction injection into mice kidney, Keywords: Kidney, Drugs, Delivery, Surgery, Injection
url http://www.sciencedirect.com/science/article/pii/S2215016118301766
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AT mohammedalhawwas adirectandnoninvasivemethodforkidneydeliveryoftherapeuticsinmice
AT xinfuzhou adirectandnoninvasivemethodforkidneydeliveryoftherapeuticsinmice
AT nimshithapavathuparambilabdulmanaph directandnoninvasivemethodforkidneydeliveryoftherapeuticsinmice
AT mohammedalhawwas directandnoninvasivemethodforkidneydeliveryoftherapeuticsinmice
AT xinfuzhou directandnoninvasivemethodforkidneydeliveryoftherapeuticsinmice
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