Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study
Abstract Background Early life exposure in the uterus had a long-term effect on children’s health. As the prevalence of allergies is increasing with a remarkable sex difference, very few studies have traced back to their early origins. We sought to investigate if maternal behavioral exposure, herein...
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doaj-0848d10a1acd4de7b605a3536203bec92020-11-25T02:43:12ZengBMCRespiratory Research1465-993X2020-09-0121111210.1186/s12931-020-01497-8Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific studyYiting Chen0Jiajun Lyu1Yuanqing Xia2Jianzhen Zhu3Shilu Tong4Yong Ying5Jiajie Qu6Shenghui Li7School of Public Health, Shanghai Jiao Tong University School of MedicineSchool of Public Health, Shanghai Jiao Tong University School of MedicineSchool of Public Health, Shanghai Jiao Tong University School of MedicineSchool of International and Public Affairs, Shanghai Jiao Tong UniversitySchool of Public Health, Shanghai Jiao Tong University School of MedicineShanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineShanghai Municipal Education CommissionSchool of Public Health, Shanghai Jiao Tong University School of MedicineAbstract Background Early life exposure in the uterus had a long-term effect on children’s health. As the prevalence of allergies is increasing with a remarkable sex difference, very few studies have traced back to their early origins. We sought to investigate if maternal behavioral exposure, herein sleep, physical activity, and screen time during pregnancy is associated with childhood respiratory allergies. The sex difference would be examined. Methods Six thousand two hundred thirty-six mother-child pairs from Shanghai Children Allergy Study (SCAS) were enrolled, The International Study of Asthma and Allergies in Childhood questionnaire was adopted to evaluate respiratory allergic diseases. Results 14.6, 16.2, and 21.0% of children had asthma, wheeze, and allergic rhinitis, respectively. Maternal short sleep duration, lack of physical activity, and too much screen exposure during pregnancy could increase the risk of childhood respiratory allergies, however, the significance was found only in males. Moreover, a dose-response trend was clearly shown, any two of the three combined could increase the risk (OR,1.921; 95% CI,1.217–3.033), and the coexistence of all three further amplified the risk (OR,2.412; 95% CI,1.489–3.906). The findings can be verified in allergen test subgroup and each single type of respiratory allergies in most cases. Conclusions Maternal unhealthy behaviors during pregnancy could increase the risk of childhood respiratory allergies with a dose-response pattern. Males were more susceptible to the association. The identification of modifiable maternal risk behaviors lies in the emphasis of intervention in early life to face up increasing childhood allergies.http://link.springer.com/article/10.1186/s12931-020-01497-8Allergic diseaseMaternal behavioral characteristicsPregnancyPreschool children |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiting Chen Jiajun Lyu Yuanqing Xia Jianzhen Zhu Shilu Tong Yong Ying Jiajie Qu Shenghui Li |
spellingShingle |
Yiting Chen Jiajun Lyu Yuanqing Xia Jianzhen Zhu Shilu Tong Yong Ying Jiajie Qu Shenghui Li Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study Respiratory Research Allergic disease Maternal behavioral characteristics Pregnancy Preschool children |
author_facet |
Yiting Chen Jiajun Lyu Yuanqing Xia Jianzhen Zhu Shilu Tong Yong Ying Jiajie Qu Shenghui Li |
author_sort |
Yiting Chen |
title |
Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study |
title_short |
Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study |
title_full |
Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study |
title_fullStr |
Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study |
title_full_unstemmed |
Effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study |
title_sort |
effect of maternal sleep, physical activity and screen time during pregnancy on the risk of childhood respiratory allergies: a sex-specific study |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-993X |
publishDate |
2020-09-01 |
description |
Abstract Background Early life exposure in the uterus had a long-term effect on children’s health. As the prevalence of allergies is increasing with a remarkable sex difference, very few studies have traced back to their early origins. We sought to investigate if maternal behavioral exposure, herein sleep, physical activity, and screen time during pregnancy is associated with childhood respiratory allergies. The sex difference would be examined. Methods Six thousand two hundred thirty-six mother-child pairs from Shanghai Children Allergy Study (SCAS) were enrolled, The International Study of Asthma and Allergies in Childhood questionnaire was adopted to evaluate respiratory allergic diseases. Results 14.6, 16.2, and 21.0% of children had asthma, wheeze, and allergic rhinitis, respectively. Maternal short sleep duration, lack of physical activity, and too much screen exposure during pregnancy could increase the risk of childhood respiratory allergies, however, the significance was found only in males. Moreover, a dose-response trend was clearly shown, any two of the three combined could increase the risk (OR,1.921; 95% CI,1.217–3.033), and the coexistence of all three further amplified the risk (OR,2.412; 95% CI,1.489–3.906). The findings can be verified in allergen test subgroup and each single type of respiratory allergies in most cases. Conclusions Maternal unhealthy behaviors during pregnancy could increase the risk of childhood respiratory allergies with a dose-response pattern. Males were more susceptible to the association. The identification of modifiable maternal risk behaviors lies in the emphasis of intervention in early life to face up increasing childhood allergies. |
topic |
Allergic disease Maternal behavioral characteristics Pregnancy Preschool children |
url |
http://link.springer.com/article/10.1186/s12931-020-01497-8 |
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