Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis

Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis

Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to inv...

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Main Authors: Lydiane Pichard, Jean-Marc Brondelo, Fabienne Becker, Romain Desprat, Frédéric De Ceuninck, Philippe Pastoureau, Danielle Noel, Christian Jorgensen, Jean-Marc Lemaitre
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120300258
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spelling doaj-085dfd862ddf4ee8868ee952060464622020-11-25T02:02:14ZengElsevierStem Cell Research1873-50612020-04-0144Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritisLydiane Pichard0Jean-Marc Brondelo1Fabienne Becker2Romain Desprat3Frédéric De Ceuninck4Philippe Pastoureau5Danielle Noel6Christian Jorgensen7Jean-Marc Lemaitre8SAFE-iPSC Facility INGESTEM, Univ Montpellier, CHU de Montpellier, Montpellier, France; Institute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, FranceInstitute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, FranceSAFE-iPSC Facility INGESTEM, Univ Montpellier, CHU de Montpellier, Montpellier, FranceSAFE-iPSC Facility INGESTEM, Univ Montpellier, CHU de Montpellier, Montpellier, FranceInstitut de Recherches Servier, Center for Therapeutic Innovation, Immuno-inflammatory Disease, Croissy sur Seine, FranceInstitut de Recherches Servier, Center for Therapeutic Innovation, Immuno-inflammatory Disease, Croissy sur Seine, FranceInstitute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, FranceInstitute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, FranceSAFE-iPSC Facility INGESTEM, Univ Montpellier, CHU de Montpellier, Montpellier, France; Institute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, France; Corresponding author at: Institute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, France.Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to investigate further, whether MSCs from patients with bone or cartilage diseases are able to provide iPSCs lines with efficient differentiation ability into MSC derivatives. For this purpose, we derived 3 stable iPSC lines from the MSCs of 3 elderly patients with osteoarthritis (OA) able to re-differentiate into MSC to make bone, cartilage and adipose tissue.http://www.sciencedirect.com/science/article/pii/S1873506120300258
collection DOAJ
language English
format Article
sources DOAJ
author Lydiane Pichard
Jean-Marc Brondelo
Fabienne Becker
Romain Desprat
Frédéric De Ceuninck
Philippe Pastoureau
Danielle Noel
Christian Jorgensen
Jean-Marc Lemaitre
spellingShingle Lydiane Pichard
Jean-Marc Brondelo
Fabienne Becker
Romain Desprat
Frédéric De Ceuninck
Philippe Pastoureau
Danielle Noel
Christian Jorgensen
Jean-Marc Lemaitre
Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis
Stem Cell Research
author_facet Lydiane Pichard
Jean-Marc Brondelo
Fabienne Becker
Romain Desprat
Frédéric De Ceuninck
Philippe Pastoureau
Danielle Noel
Christian Jorgensen
Jean-Marc Lemaitre
author_sort Lydiane Pichard
title Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis
title_short Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis
title_full Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis
title_fullStr Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis
title_full_unstemmed Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis
title_sort generation of human pluripotent stem cell lines (ipscs) from mesenchymal stem cells (mscs) from three elderly patients with osteoarthritis
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2020-04-01
description Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to investigate further, whether MSCs from patients with bone or cartilage diseases are able to provide iPSCs lines with efficient differentiation ability into MSC derivatives. For this purpose, we derived 3 stable iPSC lines from the MSCs of 3 elderly patients with osteoarthritis (OA) able to re-differentiate into MSC to make bone, cartilage and adipose tissue.
url http://www.sciencedirect.com/science/article/pii/S1873506120300258
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