Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis
Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to inv...
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doaj-085dfd862ddf4ee8868ee952060464622020-11-25T02:02:14ZengElsevierStem Cell Research1873-50612020-04-0144Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritisLydiane Pichard0Jean-Marc Brondelo1Fabienne Becker2Romain Desprat3Frédéric De Ceuninck4Philippe Pastoureau5Danielle Noel6Christian Jorgensen7Jean-Marc Lemaitre8SAFE-iPSC Facility INGESTEM, Univ Montpellier, CHU de Montpellier, Montpellier, France; Institute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, FranceInstitute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, FranceSAFE-iPSC Facility INGESTEM, Univ Montpellier, CHU de Montpellier, Montpellier, FranceSAFE-iPSC Facility INGESTEM, Univ Montpellier, CHU de Montpellier, Montpellier, FranceInstitut de Recherches Servier, Center for Therapeutic Innovation, Immuno-inflammatory Disease, Croissy sur Seine, FranceInstitut de Recherches Servier, Center for Therapeutic Innovation, Immuno-inflammatory Disease, Croissy sur Seine, FranceInstitute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, FranceInstitute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, FranceSAFE-iPSC Facility INGESTEM, Univ Montpellier, CHU de Montpellier, Montpellier, France; Institute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, France; Corresponding author at: Institute for Regenerative Medicine and Biotherapy, INSERM UMR1183, Univ Montpellier, Montpellier, France.Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to investigate further, whether MSCs from patients with bone or cartilage diseases are able to provide iPSCs lines with efficient differentiation ability into MSC derivatives. For this purpose, we derived 3 stable iPSC lines from the MSCs of 3 elderly patients with osteoarthritis (OA) able to re-differentiate into MSC to make bone, cartilage and adipose tissue.http://www.sciencedirect.com/science/article/pii/S1873506120300258 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lydiane Pichard Jean-Marc Brondelo Fabienne Becker Romain Desprat Frédéric De Ceuninck Philippe Pastoureau Danielle Noel Christian Jorgensen Jean-Marc Lemaitre |
spellingShingle |
Lydiane Pichard Jean-Marc Brondelo Fabienne Becker Romain Desprat Frédéric De Ceuninck Philippe Pastoureau Danielle Noel Christian Jorgensen Jean-Marc Lemaitre Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis Stem Cell Research |
author_facet |
Lydiane Pichard Jean-Marc Brondelo Fabienne Becker Romain Desprat Frédéric De Ceuninck Philippe Pastoureau Danielle Noel Christian Jorgensen Jean-Marc Lemaitre |
author_sort |
Lydiane Pichard |
title |
Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis |
title_short |
Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis |
title_full |
Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis |
title_fullStr |
Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis |
title_full_unstemmed |
Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis |
title_sort |
generation of human pluripotent stem cell lines (ipscs) from mesenchymal stem cells (mscs) from three elderly patients with osteoarthritis |
publisher |
Elsevier |
series |
Stem Cell Research |
issn |
1873-5061 |
publishDate |
2020-04-01 |
description |
Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to investigate further, whether MSCs from patients with bone or cartilage diseases are able to provide iPSCs lines with efficient differentiation ability into MSC derivatives. For this purpose, we derived 3 stable iPSC lines from the MSCs of 3 elderly patients with osteoarthritis (OA) able to re-differentiate into MSC to make bone, cartilage and adipose tissue. |
url |
http://www.sciencedirect.com/science/article/pii/S1873506120300258 |
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