Impact of hepatitis B virus infection on HIV response to antiretroviral therapy in a Chinese antiretroviral therapy center
Background: Co-infection with hepatitis B virus (HBV) and HIV is common in China; however, the impact of HBV on long-term antiretroviral therapy (ART) outcomes has not been fully characterized. Methods: Patients were classified as being HIV mono-infected (hepatitis B surface antigen (HBsAg)-negativ...
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doaj-086a7f1f826947f2aa43418451a9e97d2020-11-24T22:13:54ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112014-11-0128C293410.1016/j.ijid.2014.07.018Impact of hepatitis B virus infection on HIV response to antiretroviral therapy in a Chinese antiretroviral therapy centerRongrong YangXien GuiYong XiongShi-cheng GaoYajun Yan Background: Co-infection with hepatitis B virus (HBV) and HIV is common in China; however, the impact of HBV on long-term antiretroviral therapy (ART) outcomes has not been fully characterized. Methods: Patients were classified as being HIV mono-infected (hepatitis B surface antigen (HBsAg)-negative) or HIV/HBV co-infected (HBsAg-positive). The effects of HBV on HIV virological response, changes in CD4 cell counts, hepatotoxicity, and mortality among Chinese patients receiving ART were evaluated. Results: The HIV/HBV co-infection rate in our cohort was 9.9% (354/3562). Five hundred and fifty HIV mono-infected and 78 HIV/HBV co-infected individuals fulfilled the inclusion criteria. HIV/HBV co-infected individuals were less likely to achieve HIV-RNA suppression and a CD4 increase than HIV mono-infected individuals at 48 months post-ART. Greater hepatotoxicity and a more rapid occurrence of death were observed in HIV/HBV co-infected subjects. HBV-related mortality accounted for 84.2% (16/19) of the total deaths in HIV/HBV co-infected subjects. Conclusions: HBV co-infection can affect late immunological and virological responses to ART and increase the risk of hepatotoxicity. Mortality due to liver disease was high among HIV/HBV co-infected individuals in this study, despite HBV-active ART. As long as HIV/HBV co-infected persons need anti-HBV therapy, they should be recommended ART that includes agents with activity against both HIV and HBV, regardless of the CD4 cell count level. http://www.sciencedirect.com/science/article/pii/S1201971214016038Hepatitis B virusAcquired immunodeficiency syndromeHuman immunodeficiency virusHepatotoxicityEnd-stage liver diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rongrong Yang Xien Gui Yong Xiong Shi-cheng Gao Yajun Yan |
spellingShingle |
Rongrong Yang Xien Gui Yong Xiong Shi-cheng Gao Yajun Yan Impact of hepatitis B virus infection on HIV response to antiretroviral therapy in a Chinese antiretroviral therapy center International Journal of Infectious Diseases Hepatitis B virus Acquired immunodeficiency syndrome Human immunodeficiency virus Hepatotoxicity End-stage liver diseases |
author_facet |
Rongrong Yang Xien Gui Yong Xiong Shi-cheng Gao Yajun Yan |
author_sort |
Rongrong Yang |
title |
Impact of hepatitis B virus infection on HIV response to antiretroviral therapy in a Chinese antiretroviral therapy center |
title_short |
Impact of hepatitis B virus infection on HIV response to antiretroviral therapy in a Chinese antiretroviral therapy center |
title_full |
Impact of hepatitis B virus infection on HIV response to antiretroviral therapy in a Chinese antiretroviral therapy center |
title_fullStr |
Impact of hepatitis B virus infection on HIV response to antiretroviral therapy in a Chinese antiretroviral therapy center |
title_full_unstemmed |
Impact of hepatitis B virus infection on HIV response to antiretroviral therapy in a Chinese antiretroviral therapy center |
title_sort |
impact of hepatitis b virus infection on hiv response to antiretroviral therapy in a chinese antiretroviral therapy center |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 1878-3511 |
publishDate |
2014-11-01 |
description |
Background: Co-infection with hepatitis B virus (HBV) and HIV is common in China; however, the impact of HBV on long-term antiretroviral therapy (ART) outcomes has not been fully characterized.
Methods: Patients were classified as being HIV mono-infected (hepatitis B surface antigen (HBsAg)-negative) or HIV/HBV co-infected (HBsAg-positive). The effects of HBV on HIV virological response, changes in CD4 cell counts, hepatotoxicity, and mortality among Chinese patients receiving ART were evaluated.
Results: The HIV/HBV co-infection rate in our cohort was 9.9% (354/3562). Five hundred and fifty HIV mono-infected and 78 HIV/HBV co-infected individuals fulfilled the inclusion criteria. HIV/HBV co-infected individuals were less likely to achieve HIV-RNA suppression and a CD4 increase than HIV mono-infected individuals at 48 months post-ART. Greater hepatotoxicity and a more rapid occurrence of death were observed in HIV/HBV co-infected subjects. HBV-related mortality accounted for 84.2% (16/19) of the total deaths in HIV/HBV co-infected subjects.
Conclusions: HBV co-infection can affect late immunological and virological responses to ART and increase the risk of hepatotoxicity. Mortality due to liver disease was high among HIV/HBV co-infected individuals in this study, despite HBV-active ART. As long as HIV/HBV co-infected persons need anti-HBV therapy, they should be recommended ART that includes agents with activity against both HIV and HBV, regardless of the CD4 cell count level.
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topic |
Hepatitis B virus Acquired immunodeficiency syndrome Human immunodeficiency virus Hepatotoxicity End-stage liver diseases |
url |
http://www.sciencedirect.com/science/article/pii/S1201971214016038 |
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