Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies
Folate is found naturally in foods or as synthetic folic acid in dietary supplements and fortified foods. Adequate periconceptional folic acid intake can prevent neural tube defects. Folate intake impacts blood folate concentration; however, the dose-response between natural food folate and blood f...
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doaj-0872062f42ea4484be841c48e2f3a0152020-11-25T01:30:47ZengMDPI AGNutrients2072-66432015-04-01742663268610.3390/nu7042663nu7042663Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational StudiesClaire M. Marchetta0Owen J. Devine1Krista S. Crider2Becky L. Tsang3Amy M. Cordero4Yan Ping Qi5Jing Guo6Robert J. Berry7Jorge Rosenthal8Joseph Mulinare9Patricia Mersereau10Heather C. Hamner11Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN 37831, USACarter Consulting, Inc., Atlanta, GA 30345, USADivision of Birth Defects and Developmental Disabilities (DBDDD), National Center on Birth Defects and Developmental Disabilities (NCBDDD), Centers for Disease Control and Prevention, Atlanta, GA 30329, USAOak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN 37831, USADivision of Birth Defects and Developmental Disabilities (DBDDD), National Center on Birth Defects and Developmental Disabilities (NCBDDD), Centers for Disease Control and Prevention, Atlanta, GA 30329, USAOak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN 37831, USAAcentia, Falls Church, VA 22042, USADivision of Birth Defects and Developmental Disabilities (DBDDD), National Center on Birth Defects and Developmental Disabilities (NCBDDD), Centers for Disease Control and Prevention, Atlanta, GA 30329, USADivision of Birth Defects and Developmental Disabilities (DBDDD), National Center on Birth Defects and Developmental Disabilities (NCBDDD), Centers for Disease Control and Prevention, Atlanta, GA 30329, USACarter Consulting, Inc., Atlanta, GA 30345, USASciMetrika, LLC, Atlanta, GA 30329, USADivision of Nutrition, Physical Activity, and Obesity (DNPAO), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Centers for Disease Control and Prevention, Atlanta, GA 30329, USAFolate is found naturally in foods or as synthetic folic acid in dietary supplements and fortified foods. Adequate periconceptional folic acid intake can prevent neural tube defects. Folate intake impacts blood folate concentration; however, the dose-response between natural food folate and blood folate concentrations has not been well described. We estimated this association among healthy females. A systematic literature review identified studies (1 1992–3 2014) with both natural food folate intake alone and blood folate concentration among females aged 12–49 years. Bayesian methods were used to estimate regression model parameters describing the association between natural food folate intake and subsequent blood folate concentration. Seven controlled trials and 29 observational studies met the inclusion criteria. For the six studies using microbiologic assay (MA) included in the meta-analysis, we estimate that a 6% (95% Credible Interval (CrI): 4%, 9%) increase in red blood cell (RBC) folate concentration and a 7% (95% CrI: 1%, 12%) increase in serum/plasma folate concentration can occur for every 10% increase in natural food folate intake. Using modeled results, we estimate that a natural food folate intake of ≥450 μg dietary folate equivalents (DFE)/day could achieve the lower bound of an RBC folate concentration (~1050 nmol/L) associated with the lowest risk of a neural tube defect. Natural food folate intake affects blood folate concentration and adequate intakes could help women achieve a RBC folate concentration associated with a risk of 6 neural tube defects/10,000 live births.http://www.mdpi.com/2072-6643/7/4/2663food folateserum/plasma folateRBC folate |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claire M. Marchetta Owen J. Devine Krista S. Crider Becky L. Tsang Amy M. Cordero Yan Ping Qi Jing Guo Robert J. Berry Jorge Rosenthal Joseph Mulinare Patricia Mersereau Heather C. Hamner |
spellingShingle |
Claire M. Marchetta Owen J. Devine Krista S. Crider Becky L. Tsang Amy M. Cordero Yan Ping Qi Jing Guo Robert J. Berry Jorge Rosenthal Joseph Mulinare Patricia Mersereau Heather C. Hamner Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies Nutrients food folate serum/plasma folate RBC folate |
author_facet |
Claire M. Marchetta Owen J. Devine Krista S. Crider Becky L. Tsang Amy M. Cordero Yan Ping Qi Jing Guo Robert J. Berry Jorge Rosenthal Joseph Mulinare Patricia Mersereau Heather C. Hamner |
author_sort |
Claire M. Marchetta |
title |
Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies |
title_short |
Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies |
title_full |
Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies |
title_fullStr |
Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies |
title_full_unstemmed |
Assessing the Association between Natural Food Folate Intake and Blood Folate Concentrations: A Systematic Review and Bayesian Meta-Analysis of Trials and Observational Studies |
title_sort |
assessing the association between natural food folate intake and blood folate concentrations: a systematic review and bayesian meta-analysis of trials and observational studies |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2015-04-01 |
description |
Folate is found naturally in foods or as synthetic folic acid in dietary supplements and fortified foods. Adequate periconceptional folic acid intake can prevent neural tube defects. Folate intake impacts blood folate concentration; however, the dose-response between natural food folate and blood folate concentrations has not been well described. We estimated this association among healthy females. A systematic literature review identified studies (1 1992–3 2014) with both natural food folate intake alone and blood folate concentration among females aged 12–49 years. Bayesian methods were used to estimate regression model parameters describing the association between natural food folate intake and subsequent blood folate concentration. Seven controlled trials and 29 observational studies met the inclusion criteria. For the six studies using microbiologic assay (MA) included in the meta-analysis, we estimate that a 6% (95% Credible Interval (CrI): 4%, 9%) increase in red blood cell (RBC) folate concentration and a 7% (95% CrI: 1%, 12%) increase in serum/plasma folate concentration can occur for every 10% increase in natural food folate intake. Using modeled results, we estimate that a natural food folate intake of ≥450 μg dietary folate equivalents (DFE)/day could achieve the lower bound of an RBC folate concentration (~1050 nmol/L) associated with the lowest risk of a neural tube defect. Natural food folate intake affects blood folate concentration and adequate intakes could help women achieve a RBC folate concentration associated with a risk of 6 neural tube defects/10,000 live births. |
topic |
food folate serum/plasma folate RBC folate |
url |
http://www.mdpi.com/2072-6643/7/4/2663 |
work_keys_str_mv |
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