The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future

The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future

Breast cancer is the most prevalent and incident female neoplasm worldwide. Although survival rates have considerably improved, it is still the leading cause of cancer-related mortality in women. MicroRNAs are small non-coding RNA molecules that regulate the posttranscriptional expression of a wide...

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Main Authors: Miguel A. Ortega, Oscar Fraile-Martínez, Luis G. Guijarro, Carlos Casanova, Santiago Coca, Melchor Álvarez-Mon, Julia Buján, Natalio García-Honduvilla, Ángel Asúnsolo
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
breast cancer
microRNAs
mitochondria
mitomiR
translational medicine
Online Access:https://www.mdpi.com/2072-6694/12/9/2443
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spelling doaj-087b15f94672428884e61111b2ea477c2020-11-25T03:48:03ZengMDPI AGCancers2072-66942020-08-01122443244310.3390/cancers12092443The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and FutureMiguel A. Ortega0Oscar Fraile-Martínez1Luis G. Guijarro2Carlos Casanova3Santiago Coca4Melchor Álvarez-Mon5Julia Buján6Natalio García-Honduvilla7Ángel Asúnsolo8Department of Medicine and Medical Specialities, Unit of Histology and Pathology, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Unit of Histology and Pathology, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of System Biology, Unit of Biochemistry and Molecular Biology (CIBEREHD), University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Unit of Histology and Pathology, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Unit of Histology and Pathology, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Unit of Histology and Pathology, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Unit of Histology and Pathology, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Unit of Histology and Pathology, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, SpainBreast cancer is the most prevalent and incident female neoplasm worldwide. Although survival rates have considerably improved, it is still the leading cause of cancer-related mortality in women. MicroRNAs are small non-coding RNA molecules that regulate the posttranscriptional expression of a wide variety of genes. Although it is usually located in the cytoplasm, several studies have detected a regulatory role of microRNAs in other cell compartments such as the nucleus or mitochondrion, known as “mitomiRs”. MitomiRs are essential modulators of mitochondrion tasks and their abnormal expression has been linked to the aetiology of several human diseases related to mitochondrial dysfunction, including breast cancer. This review aims to examine basic knowledge of the role of mitomiRs in breast cancer and discusses their prospects as biomarkers or therapeutic targets.https://www.mdpi.com/2072-6694/12/9/2443breast cancermicroRNAsmitochondriamitomiRtranslational medicine
collection DOAJ
language English
format Article
sources DOAJ
author Miguel A. Ortega
Oscar Fraile-Martínez
Luis G. Guijarro
Carlos Casanova
Santiago Coca
Melchor Álvarez-Mon
Julia Buján
Natalio García-Honduvilla
Ángel Asúnsolo
spellingShingle Miguel A. Ortega
Oscar Fraile-Martínez
Luis G. Guijarro
Carlos Casanova
Santiago Coca
Melchor Álvarez-Mon
Julia Buján
Natalio García-Honduvilla
Ángel Asúnsolo
The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future
Cancers
breast cancer
microRNAs
mitochondria
mitomiR
translational medicine
author_facet Miguel A. Ortega
Oscar Fraile-Martínez
Luis G. Guijarro
Carlos Casanova
Santiago Coca
Melchor Álvarez-Mon
Julia Buján
Natalio García-Honduvilla
Ángel Asúnsolo
author_sort Miguel A. Ortega
title The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future
title_short The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future
title_full The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future
title_fullStr The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future
title_full_unstemmed The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future
title_sort regulatory role of mitochondrial micrornas (mitomirs) in breast cancer: translational implications present and future
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2020-08-01
description Breast cancer is the most prevalent and incident female neoplasm worldwide. Although survival rates have considerably improved, it is still the leading cause of cancer-related mortality in women. MicroRNAs are small non-coding RNA molecules that regulate the posttranscriptional expression of a wide variety of genes. Although it is usually located in the cytoplasm, several studies have detected a regulatory role of microRNAs in other cell compartments such as the nucleus or mitochondrion, known as “mitomiRs”. MitomiRs are essential modulators of mitochondrion tasks and their abnormal expression has been linked to the aetiology of several human diseases related to mitochondrial dysfunction, including breast cancer. This review aims to examine basic knowledge of the role of mitomiRs in breast cancer and discusses their prospects as biomarkers or therapeutic targets.
topic breast cancer
microRNAs
mitochondria
mitomiR
translational medicine
url https://www.mdpi.com/2072-6694/12/9/2443
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