Primary Hepatosplenic Large B-Cell Lymphoma

Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas lim...

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Main Authors: M.R. Morales-Polanco, R. Drijansky-Morgenstern, E. Murillo-Meza, E. Gómez-Morales
Format: Article
Language:English
Published: Karger Publishers 2008-03-01
Series:Case Reports in Gastroenterology
Subjects:
Online Access:http://www.karger.com/Article/FullText/120757
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spelling doaj-088b144607f741968593c438940d4cc42020-11-24T22:37:21ZengKarger PublishersCase Reports in Gastroenterology1662-06312008-03-012110911510.1159/000120757120757Primary Hepatosplenic Large B-Cell LymphomaM.R. Morales-PolancoR. Drijansky-MorgensternE. Murillo-MezaE. Gómez-MoralesDiffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had <2 months of evolution prior to diagnosis, prominent B symptoms, splenomegaly in three and hepatomegaly in two, none with lymph node involvement. All had thrombocytopenia and abnormal liver function tests; three had anemia and elevated serum lactic dehydrogenase levels, two with hemophagocytosis in bone marrow. Because of the previously mentioned data, it can be stated that primary hepatosplenic lymphoma is an uncommon and aggressive form of disease that requires immediate recognition and treatment.http://www.karger.com/Article/FullText/120757Large B-cell lymphomaPrimary extranodal lymphomaHepatosplenic
collection DOAJ
language English
format Article
sources DOAJ
author M.R. Morales-Polanco
R. Drijansky-Morgenstern
E. Murillo-Meza
E. Gómez-Morales
spellingShingle M.R. Morales-Polanco
R. Drijansky-Morgenstern
E. Murillo-Meza
E. Gómez-Morales
Primary Hepatosplenic Large B-Cell Lymphoma
Case Reports in Gastroenterology
Large B-cell lymphoma
Primary extranodal lymphoma
Hepatosplenic
author_facet M.R. Morales-Polanco
R. Drijansky-Morgenstern
E. Murillo-Meza
E. Gómez-Morales
author_sort M.R. Morales-Polanco
title Primary Hepatosplenic Large B-Cell Lymphoma
title_short Primary Hepatosplenic Large B-Cell Lymphoma
title_full Primary Hepatosplenic Large B-Cell Lymphoma
title_fullStr Primary Hepatosplenic Large B-Cell Lymphoma
title_full_unstemmed Primary Hepatosplenic Large B-Cell Lymphoma
title_sort primary hepatosplenic large b-cell lymphoma
publisher Karger Publishers
series Case Reports in Gastroenterology
issn 1662-0631
publishDate 2008-03-01
description Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had <2 months of evolution prior to diagnosis, prominent B symptoms, splenomegaly in three and hepatomegaly in two, none with lymph node involvement. All had thrombocytopenia and abnormal liver function tests; three had anemia and elevated serum lactic dehydrogenase levels, two with hemophagocytosis in bone marrow. Because of the previously mentioned data, it can be stated that primary hepatosplenic lymphoma is an uncommon and aggressive form of disease that requires immediate recognition and treatment.
topic Large B-cell lymphoma
Primary extranodal lymphoma
Hepatosplenic
url http://www.karger.com/Article/FullText/120757
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AT rdrijanskymorgenstern primaryhepatospleniclargebcelllymphoma
AT emurillomeza primaryhepatospleniclargebcelllymphoma
AT egomezmorales primaryhepatospleniclargebcelllymphoma
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