A review of controlled drug delivery systems based on cells and cell membranes

Novel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the applicati...

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Main Authors: Seyed Mohammad Zargar, Darioush Khodabakhshi Hafshejani, Asghar Eskandarinia, Mohamad Rafienia, Anousheh Zargar Kharazi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Journal of Medical Signals and Sensors
Subjects:
Online Access:http://www.jmssjournal.net/article.asp?issn=2228-7477;year=2019;volume=9;issue=3;spage=181;epage=189;aulast=Zargar
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spelling doaj-088d3aba35c64d4ea7c938e3db5a91a72020-11-25T02:41:58ZengWolters Kluwer Medknow PublicationsJournal of Medical Signals and Sensors2228-74772019-01-019318118910.4103/jmss.JMSS_53_18A review of controlled drug delivery systems based on cells and cell membranesSeyed Mohammad ZargarDarioush Khodabakhshi HafshejaniAsghar EskandariniaMohamad RafieniaAnousheh Zargar KharaziNovel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the application of micro- and nano-carriers is confronted with some challenges such as rapid clearance and inefficient targeting. In addition, since cell systems can be an appropriate alternative to micro- and nano-particles, they have been used as biological carriers. In general, features such as stable release into blood, slow clearance, efficient targeting, and high biocompatibility are the main properties of cells applied as drug carriers. Furthermore, some cells such as erythrocytes, leukocytes, stem cells, and platelets have been used as release systems. Hence, most common cells that were used as aforementioned release systems are going to be presented in this review article.http://www.jmssjournal.net/article.asp?issn=2228-7477;year=2019;volume=9;issue=3;spage=181;epage=189;aulast=ZargarDrug deliveryerythrocytesmacrophagesplateletsstem cells
collection DOAJ
language English
format Article
sources DOAJ
author Seyed Mohammad Zargar
Darioush Khodabakhshi Hafshejani
Asghar Eskandarinia
Mohamad Rafienia
Anousheh Zargar Kharazi
spellingShingle Seyed Mohammad Zargar
Darioush Khodabakhshi Hafshejani
Asghar Eskandarinia
Mohamad Rafienia
Anousheh Zargar Kharazi
A review of controlled drug delivery systems based on cells and cell membranes
Journal of Medical Signals and Sensors
Drug delivery
erythrocytes
macrophages
platelets
stem cells
author_facet Seyed Mohammad Zargar
Darioush Khodabakhshi Hafshejani
Asghar Eskandarinia
Mohamad Rafienia
Anousheh Zargar Kharazi
author_sort Seyed Mohammad Zargar
title A review of controlled drug delivery systems based on cells and cell membranes
title_short A review of controlled drug delivery systems based on cells and cell membranes
title_full A review of controlled drug delivery systems based on cells and cell membranes
title_fullStr A review of controlled drug delivery systems based on cells and cell membranes
title_full_unstemmed A review of controlled drug delivery systems based on cells and cell membranes
title_sort review of controlled drug delivery systems based on cells and cell membranes
publisher Wolters Kluwer Medknow Publications
series Journal of Medical Signals and Sensors
issn 2228-7477
publishDate 2019-01-01
description Novel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the application of micro- and nano-carriers is confronted with some challenges such as rapid clearance and inefficient targeting. In addition, since cell systems can be an appropriate alternative to micro- and nano-particles, they have been used as biological carriers. In general, features such as stable release into blood, slow clearance, efficient targeting, and high biocompatibility are the main properties of cells applied as drug carriers. Furthermore, some cells such as erythrocytes, leukocytes, stem cells, and platelets have been used as release systems. Hence, most common cells that were used as aforementioned release systems are going to be presented in this review article.
topic Drug delivery
erythrocytes
macrophages
platelets
stem cells
url http://www.jmssjournal.net/article.asp?issn=2228-7477;year=2019;volume=9;issue=3;spage=181;epage=189;aulast=Zargar
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