A review of controlled drug delivery systems based on cells and cell membranes
Novel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the applicati...
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Wolters Kluwer Medknow Publications
2019-01-01
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doaj-088d3aba35c64d4ea7c938e3db5a91a72020-11-25T02:41:58ZengWolters Kluwer Medknow PublicationsJournal of Medical Signals and Sensors2228-74772019-01-019318118910.4103/jmss.JMSS_53_18A review of controlled drug delivery systems based on cells and cell membranesSeyed Mohammad ZargarDarioush Khodabakhshi HafshejaniAsghar EskandariniaMohamad RafieniaAnousheh Zargar KharaziNovel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the application of micro- and nano-carriers is confronted with some challenges such as rapid clearance and inefficient targeting. In addition, since cell systems can be an appropriate alternative to micro- and nano-particles, they have been used as biological carriers. In general, features such as stable release into blood, slow clearance, efficient targeting, and high biocompatibility are the main properties of cells applied as drug carriers. Furthermore, some cells such as erythrocytes, leukocytes, stem cells, and platelets have been used as release systems. Hence, most common cells that were used as aforementioned release systems are going to be presented in this review article.http://www.jmssjournal.net/article.asp?issn=2228-7477;year=2019;volume=9;issue=3;spage=181;epage=189;aulast=ZargarDrug deliveryerythrocytesmacrophagesplateletsstem cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seyed Mohammad Zargar Darioush Khodabakhshi Hafshejani Asghar Eskandarinia Mohamad Rafienia Anousheh Zargar Kharazi |
spellingShingle |
Seyed Mohammad Zargar Darioush Khodabakhshi Hafshejani Asghar Eskandarinia Mohamad Rafienia Anousheh Zargar Kharazi A review of controlled drug delivery systems based on cells and cell membranes Journal of Medical Signals and Sensors Drug delivery erythrocytes macrophages platelets stem cells |
author_facet |
Seyed Mohammad Zargar Darioush Khodabakhshi Hafshejani Asghar Eskandarinia Mohamad Rafienia Anousheh Zargar Kharazi |
author_sort |
Seyed Mohammad Zargar |
title |
A review of controlled drug delivery systems based on cells and cell membranes |
title_short |
A review of controlled drug delivery systems based on cells and cell membranes |
title_full |
A review of controlled drug delivery systems based on cells and cell membranes |
title_fullStr |
A review of controlled drug delivery systems based on cells and cell membranes |
title_full_unstemmed |
A review of controlled drug delivery systems based on cells and cell membranes |
title_sort |
review of controlled drug delivery systems based on cells and cell membranes |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Medical Signals and Sensors |
issn |
2228-7477 |
publishDate |
2019-01-01 |
description |
Novel drug delivery systems have ameliorated drugs' pharmacokinetics and declined undesired ramifications while led to a better patient compliance by extending the time of release. In fact, although there has been a multitude of encouraging achievements in controlled drug release, the application of micro- and nano-carriers is confronted with some challenges such as rapid clearance and inefficient targeting. In addition, since cell systems can be an appropriate alternative to micro- and nano-particles, they have been used as biological carriers. In general, features such as stable release into blood, slow clearance, efficient targeting, and high biocompatibility are the main properties of cells applied as drug carriers. Furthermore, some cells such as erythrocytes, leukocytes, stem cells, and platelets have been used as release systems. Hence, most common cells that were used as aforementioned release systems are going to be presented in this review article. |
topic |
Drug delivery erythrocytes macrophages platelets stem cells |
url |
http://www.jmssjournal.net/article.asp?issn=2228-7477;year=2019;volume=9;issue=3;spage=181;epage=189;aulast=Zargar |
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