Cyanobacteria from Terrestrial and Marine Sources Contain Apoptogens Able to Overcome Chemoresistance in Acute Myeloid Leukemia Cells

Cyanobacteria from Terrestrial and Marine Sources Contain Apoptogens Able to Overcome Chemoresistance in Acute Myeloid Leukemia Cells

In this study, we investigated forty cyanobacterial isolates from biofilms, gastropods, brackish water and symbiotic lichen habitats. Their aqueous and organic extracts were used to screen for apoptosis-inducing activity against acute myeloid leukemia cells. A total of 28 extracts showed cytotoxicit...

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Bibliographic Details
Main Authors: Liwei Liu, Lars Herfindal, Jouni Jokela, Tania Keiko Shishido, Matti Wahlsten, Stein Ove Døskeland, Kaarina Sivonen
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Marine Drugs
Subjects:
cyanobacteria
acute myeloid leukemia
hepatocyte
apoptosis
p53
Bcl-2
microcystin
nodularin
Online Access:http://www.mdpi.com/1660-3397/12/4/2036

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