Effect of ginkgo capsules combined with secondary preventive drugs on the endothelial injury and plaque properties of patients with hypertension complicated by carotid atherosclerosis
Objective: To study the effect of ginkgo capsules combined with secondary preventive drugs on the endothelial injury and plaque properties of patients with hypertension complicated by carotid atherosclerosis. Methods: A total of 178 patients with hypertension complicated by carotid atherosclerosi...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-10-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201719/05.pdf |
Summary: | Objective: To study the effect of ginkgo capsules combined with secondary preventive drugs
on the endothelial injury and plaque properties of patients with hypertension complicated
by carotid atherosclerosis. Methods: A total of 178 patients with hypertension complicated
by carotid atherosclerosis who were treated in Chengyue Community Health Service Center
of Xisaishan District Huangshi City Hubei Province between February 2015 and January
2017 were collected and randomly divided into two groups. Control group were treated with
conventional secondary preventive drugs, and observation group were treated with ginkgo
capsules combined with secondary preventive drugs. The differences in serum endothelial
injury indexes and lipid metabolism indexes as well as carotid artery ultrasound parameters
were compared between the two groups before and after treatment. Results: Before treatment,
endothelial injury indexes and lipid metabolism indexes as well as carotid artery ultrasound
parameters were not significantly different between two groups. After treatment, serum ET,
AngⅡ, TC, LDL-C and LpA contents as well as carotid artery ultrasound parameters DS and
AS levels of observation group were lower than those of control group while serum NO and
HDL-C contents as well as carotid artery ultrasound parameter MLD level were higher than
those of control group. Conclusion: Ginkgo capsule combined with secondary preventive
drugs can effectively reduce the endothelial injury and stabilize the plaques in patients with
hypertension complicated by carotid atherosclerosis. |
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ISSN: | 1007-1237 1007-1237 |