Mineralocorticoid Receptor Signaling as a Therapeutic Target for Renal and Cardiac Fibrosis

Mineralocorticoid Receptor Signaling as a Therapeutic Target for Renal and Cardiac Fibrosis

Activation of the mineralocorticoid receptor (MR) plays important roles in both physiological and pathological events. Blockade of MR signaling with MR antagonists (MRAs) has been used clinically to treat kidney and cardiac disease associated with hypertension and other chronic diseases, resulting i...

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Bibliographic Details
Main Authors: Greg H. Tesch, Morag J. Young
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
mineralocorticoid receptor
aldosterone
kidney
cardiac
fibrosis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00313/full

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