When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics
Bacterial resistance to antibiotics poses enormous health and economic burdens to our society, and it is of the essence to explore old and new ways to deal with these problems. Here we review the current status of multi-resistance genes and how they spread among bacteria. We discuss strategies to de...
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Online Access: | https://doi.org/10.1515/bmc-2018-0021 |
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doaj-08967682c08f4ea0a0166d30fffdbef32021-09-05T20:42:35ZengDe GruyterBiomolecular Concepts1868-50211868-503X2018-12-019121622610.1515/bmc-2018-0021bmc-2018-0021When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to AntibioticsBravo Alicia0Ruiz-Cruz Sofia1Alkorta Itziar2Espinosa Manuel3Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, 28040Madrid, SpainCentro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, 28040Madrid, SpainInstituto BIOFISIKA (CSIC, UPV/EHU), Departamento de Bioquímica y Biología Molecular, Universidad del Pais Vasco, P.O. Box 644, 48080Bilbao, SpainCentro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu, 9, 28040Madrid, SpainBacterial resistance to antibiotics poses enormous health and economic burdens to our society, and it is of the essence to explore old and new ways to deal with these problems. Here we review the current status of multi-resistance genes and how they spread among bacteria. We discuss strategies to deal with resistant bacteria, namely the search for new targets and the use of inhibitors of protein-protein interactions, fragment-based methods, or modified antisense RNAs. Finally, we discuss integrated approaches that consider bacterial populations and their niches, as well as the role of global regulators that activate and/or repress the expression of multiple genes in fluctuating environments and, therefore, enable resistant bacteria to colonize new niches. Understanding how the global regulatory circuits work is, probably, the best way to tackle bacterial resistance.https://doi.org/10.1515/bmc-2018-0021antibiotic resistancesuperbugstensegritybacterial colonizationniches |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bravo Alicia Ruiz-Cruz Sofia Alkorta Itziar Espinosa Manuel |
spellingShingle |
Bravo Alicia Ruiz-Cruz Sofia Alkorta Itziar Espinosa Manuel When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics Biomolecular Concepts antibiotic resistance superbugs tensegrity bacterial colonization niches |
author_facet |
Bravo Alicia Ruiz-Cruz Sofia Alkorta Itziar Espinosa Manuel |
author_sort |
Bravo Alicia |
title |
When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics |
title_short |
When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics |
title_full |
When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics |
title_fullStr |
When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics |
title_full_unstemmed |
When Humans Met Superbugs: Strategies to Tackle Bacterial Resistances to Antibiotics |
title_sort |
when humans met superbugs: strategies to tackle bacterial resistances to antibiotics |
publisher |
De Gruyter |
series |
Biomolecular Concepts |
issn |
1868-5021 1868-503X |
publishDate |
2018-12-01 |
description |
Bacterial resistance to antibiotics poses enormous health and economic burdens to our society, and it is of the essence to explore old and new ways to deal with these problems. Here we review the current status of multi-resistance genes and how they spread among bacteria. We discuss strategies to deal with resistant bacteria, namely the search for new targets and the use of inhibitors of protein-protein interactions, fragment-based methods, or modified antisense RNAs. Finally, we discuss integrated approaches that consider bacterial populations and their niches, as well as the role of global regulators that activate and/or repress the expression of multiple genes in fluctuating environments and, therefore, enable resistant bacteria to colonize new niches. Understanding how the global regulatory circuits work is, probably, the best way to tackle bacterial resistance. |
topic |
antibiotic resistance superbugs tensegrity bacterial colonization niches |
url |
https://doi.org/10.1515/bmc-2018-0021 |
work_keys_str_mv |
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