Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3–4 months beginn...
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doaj-089fe71828fa4584a048875ff052ead42021-03-20T04:52:56ZengElsevierNeurobiology of Disease1095-953X2006-09-01233563572Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic miceM. Oksman0H. Iivonen1E. Hogyes2Z. Amtul3B. Penke4I. Leenders5L. Broersen6D. Lütjohann7T. Hartmann8H. Tanila9Department of Neuroscience and Neurology, University of Kuopio, FinlandDepartment of Neuroscience and Neurology, University of Kuopio, FinlandCenter for Molecular Biology, University of Heidelberg, GermanyCenter for Molecular Biology, University of Heidelberg, GermanyProtein Chemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, HungaryBioMedical Research department, Numico Research BV, Wageningen, NetherlandsBioMedical Research department, Numico Research BV, Wageningen, NetherlandsDepartment of Clinical Pharmacology, University of Bonn, GermanyCenter for Molecular Biology, University of Heidelberg, GermanyDepartment of Neurobiology, A.I.Virtanen Institute, University of Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Finland; Corresponding author. Department of Neurobiology, A.I.Virtanen Institute, Univ. Kuopio, Neulaniementie 2/PO Box 1627, 70211 Kuopio, Finland. Fax: +358 17 163030.The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3–4 months beginning at a young adult age (6 months). Hippocampal Aβ levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Aβ levels compared to regular (soy oil based) diet. DHA diet also decreased the number of activated microglia in hippocampus and increased exploratory activity of transgenic mice, but did not improve their spatial learning in the water maze. The favorable effect of DHA on Aβ production was verified in two different cell lines. Regulation of dietary lipid intake may offer a new tool to reduce the risk of Alzheimer's disease at the population level.http://www.sciencedirect.com/science/article/pii/S0969996106001008LipidDHAPUFAOmega-3n-3Alzheimer's disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Oksman H. Iivonen E. Hogyes Z. Amtul B. Penke I. Leenders L. Broersen D. Lütjohann T. Hartmann H. Tanila |
spellingShingle |
M. Oksman H. Iivonen E. Hogyes Z. Amtul B. Penke I. Leenders L. Broersen D. Lütjohann T. Hartmann H. Tanila Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice Neurobiology of Disease Lipid DHA PUFA Omega-3 n-3 Alzheimer's disease |
author_facet |
M. Oksman H. Iivonen E. Hogyes Z. Amtul B. Penke I. Leenders L. Broersen D. Lütjohann T. Hartmann H. Tanila |
author_sort |
M. Oksman |
title |
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice |
title_short |
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice |
title_full |
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice |
title_fullStr |
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice |
title_full_unstemmed |
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice |
title_sort |
impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in app/ps1 transgenic mice |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2006-09-01 |
description |
The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3–4 months beginning at a young adult age (6 months). Hippocampal Aβ levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Aβ levels compared to regular (soy oil based) diet. DHA diet also decreased the number of activated microglia in hippocampus and increased exploratory activity of transgenic mice, but did not improve their spatial learning in the water maze. The favorable effect of DHA on Aβ production was verified in two different cell lines. Regulation of dietary lipid intake may offer a new tool to reduce the risk of Alzheimer's disease at the population level. |
topic |
Lipid DHA PUFA Omega-3 n-3 Alzheimer's disease |
url |
http://www.sciencedirect.com/science/article/pii/S0969996106001008 |
work_keys_str_mv |
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