Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3–4 months beginn...

Full description

Bibliographic Details
Main Authors: M. Oksman, H. Iivonen, E. Hogyes, Z. Amtul, B. Penke, I. Leenders, L. Broersen, D. Lütjohann, T. Hartmann, H. Tanila
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neurobiology of Disease
Subjects:
Lipid
DHA
PUFA
Omega-3
n-3
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001008

Similar Items

Similar Items